检验医学与临床Issue(z1)：277-279,3.DOI:10.3969/j.issn.1672-9455.2014.25.142
血管内皮生长因子测定在鉴别良恶性胸腔积液中的意义
Study about determination of vascular endothelial growth factor for identifying benign and malignant pleural effusions
邓文松 1马巧玲 1刘晶 1张晓云1
作者信息
- 1. 中国人民解放军第一八四医院检验科，江西鹰潭 335000
- 折叠
摘要
Abstract
Objective To explore the value of vascular endothelial growth factor (VEGF)in the serum and pleural effusion for identifying benign and malignant pleural effusions.Methods Ninety six patients diagnosed with pleural effusion were collected from the first eight four hospital of PLA ,51 patients with malignant pleural effusion divided as malignant group;45 patients with benign pleural effusion was divied into benign group,45 health people as the control group.electrochemiluminescence immunoassay method was used to detect the VEGF.Results In the malignant group ,the serum VEGF level was (90.87±35.36)pg/mL,the VEGF level of pleural effusion was (985. 36±523.63)pg/mL.In the benign group,the serum VEGF level was (52.69±20.33)pg/mL,VEGF levels of pleu-ral effusion was (515.75±355.90)pg/mL.The serum level of VEGF in healthy control group was (30.88±7.22) pg/mL.In the benign group,the serum and pleural effusion VEGF levels of empyema patients were similar to that of the malignant pleural effusion group,the difference had no significant (P >0.05).The serum and pleural effusion VEGF levels in patients of the malignant group were significant higher than that of the patients in the benign group (P <0.05).The serum VEGF level was significant higher than that of the control group(P < 0.05).The serum VEGF level of lung cancer group was significantly higher than that of tuberculous pleurisy group (P <0.05).There was no significant different among different pathological types of lung cancer(P >0.05).In addition,the serum and pleural effusion level (109.89±40.88 pg/mL;1 175.66±684.28 pg/mL)of the initial treatment of lung cancer pa-tients with metastasis were significantly higher than those in no distant metastasis group (71.79 ± 36.37 pg/mL;803.04±480.34 pg/mL)(P < 0.05).Conclusion Detection of VEGF level in the serum and pleural effusion has clinical significance for the diagnosis and differential diagnosis of benign and malignant pleural effusion.The determi-nation of VEGF could provide effective reference for whether the cancer have transferred .The detection of VEGF in different pathological types of lung cancer has no clinical significance.The VEGF level in the pleural effusion was significantly higher than that in serum.关键词
肿瘤/结核/胸腔积液/血管内皮生长因子/血管内皮生长因子受体Key words
tumor/tuberculosis/pleurol effusion/vascalar endothelal growth factor/vascaler endo-theal growth fector receptor引用本文复制引用
邓文松,马巧玲,刘晶,张晓云..血管内皮生长因子测定在鉴别良恶性胸腔积液中的意义[J].检验医学与临床,2014,(z1):277-279,3.
