检验医学与临床Issue(1)：14-15,18,3.DOI:10.3969/j.issn.1672-9455.2015.01.006
凝血及纤溶因子水平对新生儿弥散性血管内凝血的诊断价值
Diagnostic value of coagulation and fibrinolytic factors levels in neonatal DIC
摘要
Abstract
Objective To explore the value of plasma TAT ,D‐D and FDP detection in early diagnosis of neo‐natal disseminated intravascular coagulation (DIC) .Methods 105 neonatal cases of critically ill in our hospital were taken as the study group ,all cases had the neonatal critical illness score of ≤ 90;among them ,57 cases were pre‐DIC ;contemporaneous 60 healthy neonates were selected as the control group .Pre‐DIC was treated with low dose heparin .The plasma D‐D ,TAT and FDP levels were compared among various groups .Results Compared with the control group ,the plasma D‐D ,TAT and FDP levels in the critically ill group were increased significantly ,the differ‐ence was statistically significant between the two groups (P< 0 .05);the plasma D‐D ,TAT and FDP levels after treatment in the pre‐DIC group were decreased to the normal level ,compared with before treatment ,the difference was statistically significant(P<0 .05) .The correlation analysis showed that the significantly negative correlation ex‐isted between plasma D‐D ,TAT and FDP levels with the critical illness score (P<0 .05);the combined detection of D‐D ,TAT and FDP could significantly improved the sensitivity and specificity of diagnosis .Conclusion Plasma D‐D , TAT and FDP detection can be used as the basis for early diagnosis and interventional treatment of neonatal DIC .关键词
凝血酶-抗凝血酶复合物/D-二聚体/纤维蛋白原降解产物/弥散性血管内凝血Key words
T A T/D-D/FDP/DIC引用本文复制引用
袁启明,张宏杰,张任..凝血及纤溶因子水平对新生儿弥散性血管内凝血的诊断价值[J].检验医学与临床,2015,(1):14-15,18,3.基金项目
湖北省卫生厅基金项目（WJ01564）。 （）
