检验医学与临床Issue(1)：19-21,25,4.DOI:10.3969/j.issn.1672-9455.2015.01.008
纳米羟基磷灰石／硫酸钙复合人工骨顺铂缓释系统注射液的制备与研究
Preparation and study of α-CSF-nano-(HA)/PHBV-PEG cis-platinum sustained release system injection
摘要
Abstract
Objective To research and prepare of α‐calcium sulfate hydrate(CSH)‐nano‐hydroxyapatite(HA)/PHBV‐PEG cis‐platinum drug release system to provide the new type local drug sustained release system for meta‐static bone tumor .Methods Cis‐platinum was loaded into n‐HA by the ion exchange method .The drug loaded n‐HA was mixed with CSH(1∶1)and coated with compomer poly(3‐hydroxybutyrate‐hydroxyvalerate)(PHBV)and poly‐ethylene glycol(PEG) .The injectableα‐CSH‐nano‐HA/PHBV‐PEG cis‐platinum sustained release microspheres were prepared .The release characteristics ,injectability and mechanical property were researched .Results (1) The drug release concentration of the sustained release microspheres on 1 ,3 ,5 ,7 d the cis‐platinum concentration was 97 .5 , 90 .7 ,83 .2 ,68 .5μg/mL respectively ,and then the concentration trended to be stabilized .(2)When the liquid/solid ra‐tio was 0 .7 ,the injectableα‐CSH‐nano‐HA/PHBV‐PEG cis‐platinum drug delivery system has a strong injectability . At the same time the coagulation time was extended along with the increase of liquid/solid ratio .Conclusion Theα‐CSH‐nano‐HA/PHBV‐PEG cis‐platinum drug delivery system has the better in vitro releasing effect and injection property .关键词
α-半水硫酸钙/顺铂/局部药物缓释系统Key words
α-calcium sulfate hemihydrate/cis-platinum/drug delivery system引用本文复制引用
郑燕科,张春强,汤燕飞,余佳明,江摩,汤善华..纳米羟基磷灰石／硫酸钙复合人工骨顺铂缓释系统注射液的制备与研究[J].检验医学与临床,2015,(1):19-21,25,4.基金项目
南京军区科技创新课题（08Z017）；江西省科技计划项目（2012BBG70038）。 （）
