检验医学与临床Issue(3)：304-307,4.DOI:10.3969/j.issn.1672-9455.2015.03.007
急性髓性白血病全基因组miRNA表达谱研究
Whole-genome microRNA expression research in acute myeloid leukemia
摘要
Abstract
Objective To investigate the differentially expressed microRNA (miRNA ) of bone marrow sam‐ples between the patients with acute myeloid leukemia (AML) and their controls .Methods Total RNAs were ex‐tracted from the bone marrow samples of 15 acute myeloid leukemia patients (AML group) and 10 unexplained ane‐mia or fever patients with normal bone marrow morphology (control group) ,then were applied to perform global miR‐NA expression analyses by Illumina deep sequencing technology .Results In total ,307 differentially expressed miR‐NAs including 232 up‐regulated and 75 down‐regulated miRNAs were indentified in AML group compared with con‐trol group according to the high‐throughput sequencing data .Conclusion The altered expression profile of miRNA in bone marrow samples of AML patients implies that differentially expressed miRNAs maybe plays roles in the patho‐genesis of AML .关键词
急性髓性白血病/微小RNA/Illumina测序/表达谱Key words
acute myeloid leukemia/microRNA/Illumina sequencing/expression profile引用本文复制引用
徐勇,林小聪,锦丽,李宁,张宇明,陈文标,喻祥琪,戴勇..急性髓性白血病全基因组miRNA表达谱研究[J].检验医学与临床,2015,(3):304-307,4.基金项目
深圳市知识创新计划基础研究项目（JCYJ20130401093116731）。 （）
