检验医学与临床Issue(4)：457-459,3.DOI:10.3969/j.issn.1672-9455.2015.04.010
3种细胞因子在膀胱尿路上皮癌的表达及其临床意义
The expression and clinical significance of cytokines in urothelial cell carcinoma of bladder
摘要
Abstract
Objective To investigate the expressions and clinical significance of macrophage migration inhibi‐tory factor (MIF) ,CD74 and vascular endothelial growth factor (VEGF) in the urothelial cell carcinoma of bladder . Methods The expressions of MIF ,CD74 and VEGF in 80 samples of urothelial cell carcinoma bladder tissues and 15 samples of normal bladder tissues were detected by immunohistochemistry method ,and the relationships between these indicators with clinicopathological features and prognosis were analyzed .Results The expressions of MIF , CD74 and VEGF in the bladder urothelial cell carcinoma tissues elevated significantly compared with those of the nor‐mal bladder tissues ,the differences were significant (P< 0 .05) .The expressions of MIF ,CD74 and VEGF in the tumor cell plasma were positively related with the histological classification ,pathological grade and clinical stages (P<0 .05) .The correlation analysis showed that the expression of MIF was positively related with CD 74 and VEGF in the bladder urothelial cell carcinoma tissues (r=0 .839;r=0 .753 ,P<0 .05) .Conclusion MIF might interact with CD74 to upregulate the expression of VEGF ,promote the angiogenesis and involved in the tumor development and progression ,MIF might be an effective molecular target in the treatment of urothelial cell carcinoma of the urinary bladder .关键词
膀胱肿瘤/尿路上皮癌/巨噬细胞移动抑制因子/CD74/血管内皮生长因子Key words
urothelial cell carcinoma/bladder neoplasms/macrophage migration inhibitory factor/CD74/vascular endothelial grow th factor引用本文复制引用
张宗显,王沈阳,刘翠,郭永顺,高同斌,王颖慧..3种细胞因子在膀胱尿路上皮癌的表达及其临床意义[J].检验医学与临床,2015,(4):457-459,3.基金项目
山东省潍坊市科学技术发展计划资助项目（第20121159号）。 （）
