检验医学与临床Issue(5)：580-581,584,3.DOI:10.3969/j.issn.1672-9455.2015.05.002
高危人群中红细胞 Duffy 抗原与 HIV 感染关系研究
Research on relationship between erythrocyte Duffy antigen and HIV infection in high-risk group
摘要
Abstract
Objective To investigate the relationship between erythrocyte Duffy antigen and human immunod‐eficiency virus(HIV) infection .Methods 427 cases of high‐risk group in the Liangshan Prefecture Center for Disease Control and Prevention and the Liangshan Prefecture Satation for Dermatosis and Venereal Disease Prevention and Treatment during 2008 were divided into experimental group and control group according to the results of screening and confirming test ,and cases with inconsistent results were not enrolled in this study .The serological method was a‐dopted to identify the Duffy blood group phenotype .The difference in the distribution of Duffy blood group phenotype between the two groups ,the differences of the distribution between this report and other published reports in this ar‐ea ,and HIV infection rate in different Duffy blood group phenotypes were compared .Results A total of 322 cases were carried out Duffy blood group antigen identification ,156 cases were HIV infection(experimental group)and 166 cases were non‐HIV infection(control group) .The distribution of the Duffy blood group phenotype had no statistical difference between the high‐risk population and the population of the same nationality in the same area (P>0 .05) . Among 322 high‐risk cases ,304 cases (94 .41% ) were the phenotype Fy (a+b-) ,in which the experimental group had 146 cases and the control group had 158 cases ;14 cases(4 .35% ) were the phenotype Fy(a+b+ ) ,in which the experimental group had 6 cases and the control group had 8 case;only 4 cases (1 .24% ) were phenotype Fy (a-b+ ) , which all were in the experimental group ;no case of phenotype Fy(a-b-) was detected in the two groups ;the dis‐tribution of the Duffy blood group phenotype had no statistical difference between the two groups (P> 0 .05) .The HIV infection rate in the high‐risk population had no statistical difference between the Fy (a-) and Fy(a+ ) high‐risk populations and between the Fy (b+ ) and Fy(b-) high‐risk populations(P>0 .05) .Conclusion It may not be considered from the epidemiological investigation that the erythrocyte Duffy antigen is related with the HIV infec‐tion ,which needs to conduct further deep research .关键词
Duffy抗原/趋化因子受体/人类免疫缺陷病毒/血型/高危人群Key words
Duffy antigen/receptor for chemokines/human immunodeficiency virus/blood group/high risk group引用本文复制引用
王胜蓝,吴明瞬,魏禄川..高危人群中红细胞 Duffy 抗原与 HIV 感染关系研究[J].检验医学与临床,2015,(5):580-581,584,3.基金项目
四川省卫生厅科研项目（130525）；四川省凉山州科技局科研项目（12YYJS0013）。 （）
