检验医学与临床Issue(5)：594-596,599,4.DOI:10.3969/j.issn.1672-9455.2015.05.007
育龄妇女弓形虫、风疹病毒和巨细胞病毒感染现状及其与不良妊娠结局的相关性研究
Investigation on status of toxoplasma,rubella virus and cytomegalovirus infection in childbearing-age women and its rela- tionship with adverse pregnancy outcomes
摘要
Abstract
Objective To investigate the current status of toxoplasma(TOX) ,rubella virus(RV) and cytomeg‐alovirus(CMV) infection among childbearing‐age women in Chongqing area and to preliminarily explore its relation‐ship with the adverse pregnancy outcomes .Methods Serum samples of 2 009 childbearing‐age women receiving free pre‐pregnancy checks in a District Maternity and Child Health Care Centers of Chongqing were collected from Sep .to Nov .2013 .The enzyme‐linked immunosorbent assay (ELISA) was used to detect TOX ,RV and CMV related anti‐bodies in serum samples ,and all participants were surveyed by questionnaire .The status of TOX ,RV and CMV infec‐tion in childbearing‐age women and its relationship with the adverse pregnancy outcomes were statistically analyzed . Results Of all 2 009 childbearing‐age women ,88 participants(4 .4% ) had the history of stillbirth ,and 249 partici‐pants(12 .4% ) had the history of spontaneous abortion .The total accumulative infection rates of TOX and CMV were 2 .2% and 15 .1% respectively ,and the total new infection rates were 1 .0% and 0 .4% respectively .The total positive rate of RV‐IgG was 13 .6% .There were statistically significant differences in the TOX ,RV ,CMV infection rates a‐mong the different age groups(P< 0 .05) .TOX ,RV and CMV infections were the risk factors of stillbirth (P<0 .05) ,the odds ratio(OR) values were 2 .9 ,3 .4 and 7 .8 respectively .The RV and CMV infections were the risk fac‐tors of spontaneous abortion ,and the OR values were 1 .4 and 2 .5 respectively .Conclusion The infection rates of TOX ,RV and CMV were on the high side and were the important risk factors leading to stillbirth and spontaneous a‐bortion .Therefore the pregestation screening of TOX ,RV and CMV should be strengthened among childbearing‐age women in this area ,especially for those aged 20-30 years old .关键词
育龄妇女/弓形体/风疹病毒/巨细胞病毒/不良妊娠结局Key words
childbearing-age woman/toxoplasma/rubella virus/cytomegalovirus/adverse pregnancy outcome引用本文复制引用
张世勇,王洋,陶永梅,徐晓阳,万东良,龙淑玉..育龄妇女弓形虫、风疹病毒和巨细胞病毒感染现状及其与不良妊娠结局的相关性研究[J].检验医学与临床,2015,(5):594-596,599,4.基金项目
重庆市渝中区科学委员会项目（20120301）；重庆市沙坪坝区科学委员会项目（201203）。 （）
