检验医学与临床Issue(5)：597-599,3.DOI:10.3969/j.issn.1672-9455.2015.05.008
丙型肝炎病原学不同检测方法的临床应用价值对比分析
Comparative analysis on clinical application values of different methods for detecting hepatitis C pathogens
摘要
Abstract
Objective To investigate the application value of antibody ,antigen and nucleic acid detections in the diagnosis of hepatitis C .Methods 48 anti‐HCV positive specimens in our hospital from Jan .2012 to Dec .2013 were collected .The detection results were re‐detected by HCV‐RNA ,3 kinds of antibody reagent and 2 kinds of anti‐gen reagent .Results The positive result of re‐detection was in 37 specimens by Lizhu ,in 36 specimens by Kehua ,in 36 specimens by Xinchuang ,in 21 specimens by Laibo ,in 18 specimens by Kangrun ,in 28 specimens of HCV‐RNA . Among 10 specimens of negative result re‐detected by 3 kinds of antibody reagent ,1 specimen of HCV‐RNA posi‐tive ,3 specimens of Laibo antigen positive and 1 specimen of Kangrun positive were detected out .The sensitivities of 3 kinds of antibody all were 96 .4% ,the positive predictive value was 72 .9% -75 .0% ;the sensitivity of 2 kinds of antigen reagent was 40 .0% and 83 .3% respectively ,and the positive predictive value was 57 .0% and 83 .3% respec‐tively .Conclusion The HCV antibody detection could have the higher diagnostic sensitivity ,but its specificity may be lower .Re‐detecting the anti‐HCV positive samples by using antibody plus antigen model could be of great value to the diagnosis of hepatitis C .Using HCV‐RNA for confirming the questionable specimens could be prevent misdiagno‐sis and missed diagnosis .关键词
丙型肝炎病毒/丙型肝炎病毒抗体/丙型肝炎病毒抗原/丙型肝炎病毒核酸Key words
hepatitis C virus/hepatitis C virus antibody/hepatitis C virus antigen/hepatitis C virus an-tigen RNA引用本文复制引用
龙宏洋,叶玉芬,朱学强,王涵..丙型肝炎病原学不同检测方法的临床应用价值对比分析[J].检验医学与临床,2015,(5):597-599,3.基金项目
广东省珠海市科技计划项目（2012D0401990008）。 （）
