摘要
Abstract
Objective To explore the expression of immunohistochemical markers vimentin (Vim) ,carcinoem‐bryonic antigen (CEA) ,estrogen receptor (ER) ,progesterone receptor (PR) and P16 protein in the differential diag‐nosis of endometrioid adenocarcinoma and cervical adenocarcinoma ,and to analyze its clinical significanceMethods 80 cases of endometrioid adenocarcinoma (group A) and 80 cases of cervical adenocarcinoma (group B) in our hospital from Jan .2013 to Jun .21014 were selected .The expression of Vim ,CEA ,ER and P16 protein was measured by the immunohistochemical method .The functional indexes were compared between the 3‐item combined detection of Vim , CEA and ER and the 4‐item combined detection of Vim ,CEA ,ER and P16 protein .Results The positive rates of Vim and ER in the group A were 71 .25% and 73 .75% respectively ,which were higher than those in the group B ,the differences were statistically significant (P<0 .05) .The positive rates of CEA and P16 protein in the group B were 73 .75% and 67 .50% respectively ,which were higher than those in the group A ,the differences were statistically sig‐nificant (P<0 .05) .The specificity ,sensitivity and accuracy of the 4‐item combined detection in the group A and B were 92 .43% and 98 .62% ,56 .44% and 58 .57% ,71 .21% and 74 .62% respectively ,which were higher than those of the 3‐item combined detection in the same group ,the differences were statistically significant (P<0 .05) .Conclu‐sion Vim and ER have high positive expression in endometrial adenocarcinoma tissue ,while CEA and P16 have high positive expression in cervical adenocarcinoma .p16 protein combined with traditional triple combination detection could improve the differential diagnostic accuracy of endometrial adenocarcinoma and cervical adenocarcinoma .关键词
子宫内膜样腺癌/宫颈腺癌/波形蛋白/癌胚抗原/雌激素受体Key words
endometrioid adenocarcinoma/cervical adenocarcinoma/vimentin/carcinoembryonic anti-gen/estrogen receptor
