检验医学与临床Issue(9)：1179-1182,4.DOI:10.3969/j.issn.1672-9455.2015.09.001
转化生长因子-β1与冠状动脉支架内再狭窄关系的探讨
Study on association between TGF-β1 and restenosis of coronary stenting
摘要
Abstract
Objective To explore the association between TGF‐β1 gene C‐509T single nucleotide polymor‐phism(SNP) and plasma levels of TGF‐β1 with the occurrence of coronary stent restenosis after percutaneous coro‐nary intervention(PCI) in Han nationality crowd .Methods 368 patients with successful coronary stent placement and follow‐up angiography were retrospectively included and divided into the in‐stent restenosis (ISR) group (n=152) and non in‐stent restenosis (NISR) group (n=216) .Genotyping for the C‐509T polymorphism was performed by using polymerase chain reaction‐restriction fragment length polymorphism analysis .Plasma TGF‐β1 levels were detected with the enzyme linked immuno sorbent assay(ELISA) .Results The prevalence of the TT genotype ,fre‐quency of the T allele and the concentration of TGF‐β1 in the ISR group were significantly higher than those in the NISR group .The C‐509T polymorphism was also significantly correlated with TGF‐β1 levels with the TT genotype corresponding with the highest and the CC genotype with the lowest TGF‐β1 levels in both ISR and NISR group .The TT genotype ,T allele carriers and plasma TGF‐β1 levels were significantly associated with the risk of ISR (adjusted OR=1 .82 ,1 .61 ,2 .01 ,P<0 .05) .Conclusion Higher plasma levels of TGF‐β1 ,T T homozygotes and T allele carri‐ers of TGF‐β1 C‐509T polymorphism have higher risk of ISR after coronary stenting .关键词
冠状动脉疾病/转化生长因子-β1/单核苷酸多态性/支架/冠状动脉再狭窄Key words
coronary artery diseases/transforming growth factor-β1/single nucleotide polymorphisms/stents/coronary restenosis引用本文复制引用
黄骥,王凤鸣,黄婕,唐素琼,刘筑,伊远学,王旭开,裴芳..转化生长因子-β1与冠状动脉支架内再狭窄关系的探讨[J].检验医学与临床,2015,(9):1179-1182,4.基金项目
国家自然科学基金资助项目（81200193，81370367）。 （）
