检验医学与临床Issue(9)：1193-1195,3.DOI:10.3969/j.issn.1672-9455.2015.09.006
联合检测粪便血红蛋白和转铁蛋白在肠癌疾病防治中的应用
Application of combined detection of fecal hemoglobin and transferrin in prevention and treatment of intestinal cancer disease
摘要
Abstract
Objective To investigate the application value of the combined detection of fecal hemoglobin and transferrin in the prevention and treatment of intestinal cancer disease in the community .Methods 120 cases of colo‐rectal cancer high‐risk in our hospital from August 2011 to December 2013 were selected ,including 20 cases of color‐ectal cancer ,40 cases of precancerous lesions and60 cases of colorectal polyps .All cases were performed the detection of fecal hemoglobin and transferrin and the chemical assay was performed .Results The positive rates of fecal hemo‐globin and transferrin detection for colorectal cancer ,precancerous lesions and polyps were 100 .0% ,92 .5% and 90 .0% respectively ,w hich by the chemical assay w ere 100 .0% ,77 .5% and 73 .3% respectively ,the results indicated that positive rates of the detection of fecal hemoglobin and transferring for colorectal polyps and precancerous lesions were significantly higher than those of the chemical method ,the differeces were statistically significant (P<0 .05) . The sensitivity and specificity of fecal hemoglobin and transferring detection for diagnosing colorectal cancer and pre‐cancerous lesions were significantly higher than those of the chemical method ,the differeces were statistically signifi‐cant (P<0 .05) .And the likelihood ratio and odds ratios of fecal hemoglobin and transferring detection for diagnosing colorectal cancer and precancerous lesions were also significantly higher than those of the chemical method ,the differ‐ences were statistically significant (P<0 .05) .Conclusion The application of the combined detection of fecal hemo‐globin and transferrin has very high detection rate ,sensitivity ,specificity and positive likelihood ratio in the preven‐tion and treatment of intestinal cancer disease in the community ,which is suitable for colorectal cancer screening and deserves to be promoted and applied .关键词
粪便血红蛋白/转铁蛋白/大肠癌/癌前病变/诊断Key words
fecal hemoglobin/transferrin/colorectal cancer/precancerous lesions/diagnosis引用本文复制引用
娄国平,李显东,张昭勇..联合检测粪便血红蛋白和转铁蛋白在肠癌疾病防治中的应用[J].检验医学与临床,2015,(9):1193-1195,3.基金项目
湖北省自然科学基金（2012FFB0190）。 （）
