检验医学与临床Issue(9)：1228-1230,3.DOI:10.3969/j.issn.1672-9455.2015.09.019
血流感染病原菌的临床分布及耐药性分析
Clinical distribution and drug resistance of pathogens isolated from bloodstream infections
摘要
Abstract
Objective To analyze the composition ratio ,clinical distribution and drug resistance of pathogens i‐solated from bloodstream infections (BSIs) from Shanghai Changhai hospital for guiding rational use of antibacterial drugs in clinic .Methods The identification and antimicrobial susceptibility test of pathogens causing BSIs were per‐formed by using the VITEK 2‐Compact system .The obtained data were processed with WHONET5 .6 software for evaluating the clinical distribution and drug resistance of isolated pathogens .Results Among 1 641 strains of blood‐stream infection pathogens ,373 strains(22 .74% ) were Gram‐positive bacteria ,933 strains (56 .85% ) were Enter‐obacteriaceae bacteria ,291 strians (17 .73% ) were non‐fermenters and 44 strains (2 .68% ) were fungi .The top 5 pathogens in the isolation rates were Escherichia coli ,Klebsiella pneumoniae ,Acinetobacter baumannii ,Pseudomonas aeruginosa and coagulase‐negative staphylococci (CoNS) .The antimicrobial susceptibility test showed that 61 .70% i‐solated strains of staphylococci aures were resistant to methicillin;4 .23% isolated strains of enterococci feces were resistant to vancomycin;13 .30% isolated strains of Klebsiella pneumoniae were resistant to carbapenems ;most isola‐ted strains of non‐fermenters bacteria were multi‐drug resistant .Conclusion The most common pathogens of BSIs in Changhai hospital are dominated by enterobacteriaceae bacteria ,followed by Gram‐positive bacteria and non‐fermenta‐tive bacteria .In addition to bacteria ,candidemia are more and more common in nosocomial bloodstream infection .In‐creasing attention should be paid to the pathogens causing bloodstream infections and their drug resistant trend for controlling the nosocomial infections .关键词
血流感染/病原菌/耐药性Key words
bloodstream infections/pathogen/resistant pattern引用本文复制引用
陶运娟,周跃,刘连庚,黄宏亮,秦阳华..血流感染病原菌的临床分布及耐药性分析[J].检验医学与临床,2015,(9):1228-1230,3.基金项目
国家科技部863项目子课题（2011AA02A119）。 （）
