摘要
Abstract
Objective To examine the serum levels of adiponectin and inflammatory factors in type 2 diabetes mellitus (T2DM ) patients with insulin resistance and to analyze their correlation .Methods T2DM patients (T2DM group) with insulin resistance and HOMA‐IR> 2 .69 and healthy persons (CON group) of HOMA‐IA=1 .0 were selected as the research subjects .The serum levels of adiponectin and inflammatory factors (hs‐CRP ,TNF‐α,IL‐1β, IL‐6 ,IL‐8 ,IL‐10 and IL‐18) were examined and compared between the two groups .Results The levels of hs‐CRP , TNF‐α,IL‐1β,IL‐6 ,IL‐8 and IL‐18 in the T2DM group were significantly higher those in the CON group (P<0 .05) ,while the levels of adiponectin and IL‐10 were lower than those in the CON group ,the differeces were statis‐tially significant (P<0 .05) .The adiponectin in T2DM group was negatively correlated with hs‐CRP ,TNF‐α,IL‐1β, IL‐6 ,IL‐8 and IL‐18 (rs<0 ,P<0 .05) ,but positively correlated with IL‐10 (rs >0 ,P<0 .05) .Conclusion T2DM patients with insulin resistance are in the inflammation disorder state and the adiponectin level is significantly lower than that in the healthy people .The adiponectin level is closely correlated with the inflammatory factors .关键词
2型糖尿病/胰岛素抵抗/脂联素/炎症因子Key words
type 2 diabetes mellitus/insulin resistance/adiponectin/inflammatory cytokines
