检验医学与临床Issue(10)：1339-1341,1344,4.DOI:10.3969/j.issn.1672-9455.2015.10.001
EB病毒抗体及其DNA联合检测在鼻咽癌筛查和早期诊断中的价值
Combined determination of Epstein-Barr virus-related antibodies and EBV DNA for nasopharyngeal carcinoma early di-agnosis
摘要
Abstract
Objective To evaluate the values of combined detection of Epstein‐Barr virus‐related antibodies and EBV DNA for diagnosing of early stage nasopharyngeal carcinoma (NPC) .Methods A total of 272 NPC patients were recruited in this study from July 2011 to August 2014 in the Second People′s Hospital of Guangdong Province . Euzymelinked immunosorbent assay was performed to detect RTA‐IgG ,VCA‐IgA and EA‐IgA antibody ,and real‐time fluorescent quantitative PCR for measuring EBV DNA in plasma .Results The sensitivity of the combined de‐tection for diagnosing NPC was 99 .63% .Combined detection could improve the positive rate of diagnosis for early and late stage NPC to 97 .62% (41/42) and 100 .00% (230/230) respectively .The positive rate of any two or more indicators for NPC was above 93 .00% .Conclusion Combined determination could be helpful to screen the early stage NPC ,when people has any two or more positive indicators should be suspected to have NPC .关键词
鼻咽癌/EB病毒抗体/EBV DNA/早期诊断Key words
nasopharyngeal carcinoma/Epstein-Barr virus antibody/EBV DNA/early diagnosis引用本文复制引用
邱厚匡,吴晓昀,张智,姚亚超,李磊,李亚红,张珍,李楠,严芳,李泽泳,吴春燕..EB病毒抗体及其DNA联合检测在鼻咽癌筛查和早期诊断中的价值[J].检验医学与临床,2015,(10):1339-1341,1344,4.基金项目
国家自然科学基金项目（81400639）；广州医科大学博士启动基金（2014C39）。 （）
