检验医学与临床2015，Vol.12Issue(11)：1567-1569,3.DOI:10.3969/j.issn.1672-9455.2015.11.029
脂联素及其基因多态性与某地冠心病的相关性研究
Study on relations between adiponectin and its gene polymorphism and Yao coronary heart disease of Guangxi district
刘运端1
作者信息
- 1. 广西壮族自治区玉林市红十字会医院检验科 537000
- 折叠
摘要
Abstract
Objective To investigate the difference of serum levels of adiponectin and its gene polymorphism in Yao patients with CHD of Guanxi district and Han CHD patients and Yao normal people in same region .Methods The levels of serum adiponectin in Yao CHD patients ,Han CHD patients ,Yao normal people and Han normal people (each of 100 cases)were detected by enzyme-linked immunosorbent assay (ELISA) method ,and APN+45 and APN-11377 genotyping were conducted by using PCR-RFLP .Results The levels of adiponectin in two groups of CHD pa-tients were significantly lower than same race normal group ,the difference were statically significant (P=0 .000 ;P=0 .000) .The adiponectin levels of two CHD groups was not statically significant difference (P= 0 .067);(2) The APN+45 and APN-11377 of four groups conform the Hardy-Weinberg population genetic equilibrium law (all P>0 .05);(3)The TG and GG genotype frequency of APN+45 In two CHD groups were higher than same race normal group ,but the difference of Yao CHD group and Yao normal group was no statically significant (χ2 = 8 .122 ,P=0 .017 ;χ2 =5 .121 ;P=0 .077) ,and the difference of Yao CHD group and Han CHD group were not statically signifi-cant(χ2 =1 .750 ;P=0 .417);(4) The CG and GG genotype frequency of APN-11377 in two CHD groups were higher than same race normal group ,the difference of Yao CHD group and Yao normal group was statically significant(χ2 =12 .522 ,P=0 .002 ;χ2 =17 .275 ;P=0 .000) ,and the difference of Yao CHD group and Han CHD group were not statically significant(χ2 = 0 .363;P= 0 .834) .Conclusion As with Han CHD patients ,serum low APN level and APN-11377 loci may be risk factors of Yao CHD patients .关键词
脂联素/基因多态性/瑶族/冠心病Key words
adiponectin/polymorphism/Yao nationality/coronary heart disease引用本文复制引用
刘运端..脂联素及其基因多态性与某地冠心病的相关性研究[J].检验医学与临床,2015,12(11):1567-1569,3.
