检验医学与临床Issue(12)：1659-1660,1664,3.DOI:10.3969/j.issn.1672-9455.2015.12.001
糖类抗原125、细胞角蛋白19片段、癌胚抗原在非小细胞肺癌中的临床应用价值
Explore clinical diagnosis value of CA125,CYFRA21-1 and CEA in non-small cell lung cancer
摘要
Abstract
Objective To evaluate the values of CA125 ,CYFRA21‐1 and CEA in diagnosing of non‐small cell lung cancer (NSCLC) .Methods Serum samples from 130 NSCLC patients ,80 Patients with benign lung disease and 90 healthy donors were collected to detect the level of CA125 ,CYFRA21‐1 and CEA .ROC was generated by Graph‐Pad Prism 5 .We also analyze the diagnosis efficiency of the separate and combined detection .Results ROC area un‐der curve of CA125 ,CYFRA21‐1 and CEA was 0 .836 8 ,0 .842 4 and 0 .785 2 ,separately .The sensitivity of CEA and the specificity of CYFRA21‐1 was the highest in the three serum biomarkers .The accuracy of the combined detection for CYFRA21‐1 and CEA was higher than that of the combined detection for CA125 and CEA .Conclusion Com‐bined determination of CYFRA21‐1 and CEA which is superior to combined detection of CA125 and CEA ,not only had significant values for the diagnosis of NSCLC ,but also can identify the pathological type of NSCLC .关键词
非小细胞肺癌/诊断/糖类抗原125/细胞角蛋白19片段/癌胚抗原Key words
NSCLC/diagnosis/CA125/CYFRA21-1/CEA引用本文复制引用
姚亚超,张智,李磊,严芳,邱厚匡,吴晓昀,李亚红,李泽泳,张珍,李楠..糖类抗原125、细胞角蛋白19片段、癌胚抗原在非小细胞肺癌中的临床应用价值[J].检验医学与临床,2015,(12):1659-1660,1664,3.基金项目
国家自然科学基金项目（81400639）；广州医科大学博士启动基金项目（2014C39）。 （）
