检验医学与临床Issue(13)：1850-1851,2.DOI:10.3969/j.issn.1672-9455.2015.13.013
磷霉素与4种抗菌药物对泌尿系统分离铜绿假单胞菌的协同作用研究
Study on synergy of fosfomycin combined with 4 kinds of antimicrobial agents against Pseudomonas aeruginosa strains i-solated from urinary system
黄正谷 1苏世芳1
作者信息
- 1. 重庆市公共卫生医疗救治中心检验科 400036
- 折叠
摘要
Abstract
Objective To study the in vitro antibacterial activity of fosfomycin combined with other 4 kinds of antimicrobial agents against 40 clinically isolated strains of Pseudomonas aeruginosa .Methods The bacteria were i‐solated and identified by the conventional culture and the microbiological analyzer .The drug sensitive test was per‐formed by using Kirby‐Bauer disk diffusion test and the minimal inhibitory concentration (MIC) was examined by u‐sing the agar double dilution test and the micrdilution checkerboard technique .The fractional inhibitory concentration index(FICI) was calculated .Results A total of 40 strains of Pseudomonas aeruginosa were resistant to most of anti‐bacterial agents .The fosfomycin exclusive use had a good antibacterial activity to Pseudomonas aeruginosa and the re ‐sistance rate was 37 .5% ;the combination use of fosfomycin with 4 kinds of antimicrobial agent showed the addictive action and independent action ,little synergic effect and no antagonism .Conclusion Fosfomycin is still a choice of an‐tibacterial drugs to treat the urinary tract infection induced by Pseudomonas aeruginosa .关键词
磷霉素/铜绿假单胞菌/尿路感染/协同作用Key words
fosfomycin/Pseudomonas aeruginosa/urinary tract infection/synergy引用本文复制引用
黄正谷,苏世芳..磷霉素与4种抗菌药物对泌尿系统分离铜绿假单胞菌的协同作用研究[J].检验医学与临床,2015,(13):1850-1851,2.
