检验医学与临床Issue(13)：1887-1888,2.DOI:10.3969/j.issn.1672-9455.2015.13.029
多西他赛联合顺铂或洛铂胸腔灌注治疗晚期非小细胞肺癌的疗效分析
Analysis on effect of docetaxel combined with cisplatin or lobaplatin by pleural perfusion in treatment of advanced NSCLC
冯茜茜 1张家洪1
作者信息
- 1. 华中科技大学附属荆州市中心医院呼吸内科，湖北荆州 434020
- 折叠
摘要
Abstract
Objective To observe the clinical effect and adverse reactions of docetaxel combined with lobapla ‐tin or cisplatin by pleural infusion for treating advanced non‐small cell lung cancer(NSCLC) .Methods 80 inpatients with advanced NSCLC in our hospital from January 2012 to December 2013 were randomly divided into the cisplatin group and the lobaplatin group .The two groups were treated by docetaxel by intravenous injection ,on this baseis the central venous catheter was inserted via thoracentesis to conduct pleural effusion drainage .After exhaustion of pleural effusion ,the two groups were respectively given lobaplatin and cisplatin by pleural infusion .The clinical effects and adverse reactions were compared between the two groups .Results After treatment ,the total effective rates of the lobaplatin group and the cisplatin group were 40 .0% and 37 .5% ,respectively .The adverse reactions in the two groups mainly included the neurotoxicity ,renal toxicity ,chest pain ,gastrointestinal reaction (mainly manifested by nausea and vomiting ) and bone marrow suppression(mainly manifested by WBC and PLT decreased) ,and grade Ⅰ toⅡ were predominant .Apart from neurotoxicity and bone marrow suppression ,the lobaplatin group was significantly lower than the cisplatin group in the occurrence rates of renal toxicity ,chest pain and gastrointestinal reaction ,and their severity was lighter .Conclusion Docetaxel combined with pleural perfusion of lobaplatin or cisplatin has the same effect for the treatment of advanced NSCLC ,but the adverse reactions situation of lobaplatin is better than that of cisplatin ,and this method is worthy of clinical promotion .关键词
洛铂/顺铂/多西他赛/非小细胞肺癌Key words
lobaplatin/cisplatin/docetaxel/non small cell lung cancer引用本文复制引用
冯茜茜,张家洪..多西他赛联合顺铂或洛铂胸腔灌注治疗晚期非小细胞肺癌的疗效分析[J].检验医学与临床,2015,(13):1887-1888,2.
