检验医学与临床Issue(14)：2016-2018,3.DOI:10.3969/j.issn.1672-9455.2015.14.016
rs1122608多态性与中国汉族人血脂水平的关联研究
Association study between rs1122608 and lipid levels in Chinese Han population
摘要
Abstract
Objective To study the association of rs1 122608 single nucleotide polymorphism (SNP)and serum lipid levels in the Han population.Methods A total of 204 hyperlipidemia cases as the hyperlipidemia group and 187 healthy people as the healthy control group were recruited for the study.Serum lipid levels were detected by automat-ic biochemical analyzers.The rs1 122608 polymorphism was determined by polymerase chain reaction (PCR)and high-resolution melting (HRM).The genotype and allele frequency distributions were compared between the hyper-lipidemia group and the healthy control group.Serum lipid levels among different genotype subgroups in the hyperlip-idemia group and the healthy control were compared also.Results The differences in the genotypic and allelic fre-quencies between the the hyperlipidemia group and the healthy control had no statistical significance (P >0.05).And there were no significant differences in TG,TC,HDL-C and LDL-C levels among different genotype subgroups in the hyperlipidemia group and the healthy control.Conclusion The rs1 122608 polymorphism is not associated with lipid levels in Chinese Han population.关键词
高脂血症/单核苷酸多态性/高分辨率熔解曲线Key words
hyperlipidemia/single nucleotide polymorphism/high-resolution melting引用本文复制引用
程小欢,李祖华,郑芳..rs1122608多态性与中国汉族人血脂水平的关联研究[J].检验医学与临床,2015,(14):2016-2018,3.基金项目
武汉大学中南医院院内基金(201105)。 （201105）
