口腔颌面外科杂志Issue(3)：208-213,6.DOI:10.3969/j.issn.1005-4979.2014.03.010
纯钛种植体激光-微弧氧化表面处理对早期骨结合的影响
Biological Performance of Ti Implants due to Surface Modification by Laser-micro-arc Oxidation
摘要
Abstract
Objective: To examine the physico-chemical properties and their influences to osteointegration of Ti implants due to surface modified by laser micro-arc oxidation (MAO). Methods: 16 threaded cylindrical implants were manufactured from rods of commercially pure titanium. 8 pure titanium machined surface implants were used as control group and other 8 implants which surface modified by laser-micro-arc oxidation as experimental group. Physico-chemical properties were examined by the energy dispersive spectrum (EDX), scanning electron microscopy (SEM), and Veeco roughness measurement. Ti implants were embeded on the tibia of New Zealand rabbits randomly. The rabbits were sacrificed and the tibia were retrived for observation at 2-, 4- and 6- week respectively. To evaluate the mineralization ratio, the rabbits were injected tetracycline subcutaneously at 13- day and 14- day before sampling and were injected calcein subcutaneously at 3- day and 4- day before sampling. All samples were processed for undecalcified ground sectioning. Bone implant contact (BIC) along the entire implant was calculated. Results: It was evident that implant surface in experiment groups covered with micro pores. The aperture is about 100 μ m, hole depth was 40~80 μm. MAO surface has many microporous structure. The micro hole diameter was about 1~5 μm, in which there were more small level micro hole with diameter less than 1 μm. The Ra value of control group was 179.23 nm, The Ra value of experimental group was 1.55 μm. The control group was composed of Ti elements, the experimental group was composed of Ti, 0, Ca, and P elements. The mineralization ratio between the two groups was statistically difference ( P<0.05), so as the contact ratio of osseo-implant interface (OI values). Conclusion: The microporous structure of MAO coating was formed in pure titanium implant surface through the laser-micro-arc oxidation,which has the good biocompatibility and bone conductivity, can promote osteointegration on implant surface.关键词
钛/微弧氧化/激光/种植体/骨结合/兔Key words
titanium/micro-arc oxidation/laser/implant/osteointegration/rabbit分类
医药卫生引用本文复制引用
郭泽鸿,周磊,容明灯,蒋颖,丁婧文,刘伟珍..纯钛种植体激光-微弧氧化表面处理对早期骨结合的影响[J].口腔颌面外科杂志,2014,(3):208-213,6.基金项目
国家自然科学基金(81170998)；广东省医学科研基金(B2011033) （81170998）
