口腔颌面外科杂志Issue(6)：425-428,4.DOI:10.3969/j.issn.1005-4979.2014.06.005
多孔性碳酸化羟基磷灰石支架材料体外可吸收性测定
Bioresorption of Porous Carbonated Hydroxyapatite In Vitro
摘要
Abstract
Objective: To evaluate the bioabsorbability of a novel porous carbonated hydroxyapatite (PCHA) in vitro. Methods: 15 types of PCHA samples (n=3), with different carbonate contents and porosities, were immersed at 100 mL, pH 4 acetic acid buffer solution for extraction. Hydroxyapatite (HAP) and degreased cattle bone blocks were used as control. Then 0.1 mL extracted solution was taken out at 1 h, 4 h, 8 h, 1 d, 2 d, 3 d, 4 d, 5 d and 7 d respectively for calcium analysis . Concentration curves were plotted to evaluate the absorbability of the samples. Results: Calcium concentrations in PCHA samples and cattle bone blocks all increased over time, while no obvious variations showed in HAP group. PCHA samples with higher carbonate contents and porosities showed faster calcium ion release. Calcium concentration curves in groups of 7-40, 7-60, 8-40, 8-60, 8-70, 9-70 showed better consistency with those of cattle bone blocks, indicated they had similar bioabsorbability. Conclusion: PCHA has good bioabsorbability in vitro, and the absorbability can be affected by degrees of carbonation and porosity.关键词
碳酸化羟基磷灰石/多孔性/可吸收性/组织工程Key words
carbonated apatite/porosity/absorbability/tissue engineer分类
医药卫生引用本文复制引用
周琳怡,乔亚南,刘楠,曹寅,张磊..多孔性碳酸化羟基磷灰石支架材料体外可吸收性测定[J].口腔颌面外科杂志,2014,(6):425-428,4.基金项目
国家大学生创新性实验计划项目(1504107007) （1504107007）
