兰州大学学报（医学版）Issue(3)：64-68,5.DOI:10.13885/j.issn.1000-2812.2015.03.013
中国人群X线交错互补修复基因1 Arg399Gln多态性与胃癌易感性关系的Meta分析
Association between XRCC1 Arg399Gln genetic polymorphism and gastric cancer susceptibility:a Meta-analysis
摘要
Abstract
Objective To quantitatively evaluate the relationship between XRCC1 Arg399Gln genetic polymor-phism and the susceptibility of gastric cancer. Methods A systematic search was conducted to identify case-control studies on the effect of XRCC1 Arg399Gln genetic polymorphism on the susceptibility of gastric cancer. Screening literature from the Chinese BioMedical Literature Database, China Science and Technology Journal Database, Chinese Journal Full-text Database, PudMed and EMBASE from inception to May 19th, 2013 were performed by two reviewers independently according to the inclusion and exclusion criteria. Then Meta-analysis was analyzed using statistical software StataSE12. Results Seven case-control studies with a total of 1 737 gastric cancer cases and 2 441 controls were included. The Meta-analysis found XRCC1 Arg399Gln mutation genotype (AG+GG) was associated with 1.20 times risk of gastric cancer compared with AA genotype (95%CI=1.05 to 1.38). Sensitivity analysis showed difference in the research quality with un-stable results. The Begg's funnel plot and Egger's test provided no evidence of publication bias. Conclusion XRCC1 Arg399Gln genetic polymorphism may contribute to susceptibility of gastric cancer.关键词
胃癌/X线交错互补修复基因1/基因多态性/Meta分析/病例对照Key words
gastric cancer/XRCC1 Arg399Gln/genetic polymorphism/Meta-analysis/case-control分类
医药卫生引用本文复制引用
李江奇,赵永勋,姜雷,元博,孙丽娜,梁富翔,马守成..中国人群X线交错互补修复基因1 Arg399Gln多态性与胃癌易感性关系的Meta分析[J].兰州大学学报（医学版）,2015,(3):64-68,5.基金项目
中央高校基本科研业务费专项资金项目（LZUJBKY-2013-160）；兰州大学创新创业行动计划项目 （）
