兰州大学学报（医学版）Issue(3)：69-76,8.DOI:10.13885/j.issn.1000-2812.2015.03.014
常规治疗联合连续性静脉-静脉血液滤过治疗急性呼吸窘迫综合征的Meta分析
Effectiveness of conventional treatment combined with continuous veno-venous hemofiltrationon treatment of acute respiratory distress syndrome:a Meta-analysis
摘要
Abstract
Objective To systematically review the effectiveness of conventional treatment combined with continuous veno-venous hemofiltration(CVVH)on the treatment of acute respiratory distress syndrome(AR-DS). Methods PubMed, The Cochrane Library (Issue 11, 2014), EMbase, CNKI, CBM, VIP and Wan-Fang Data for the randomized controlled studies (RCTs) related to CVVH combined conventional treatment versus conventional treatment for ARDS were searched. From inception to April 2014 two reviewers independently screened literature, extracted data, and evaluated methodological quality of included studies. Then Meta-analysis was performed using RevMan 5.2 software. Results A total of 7 RCTs and 3 q-RCTs involving 620 patients were included. The results of Meta-analysis showed that CVVH combined conventional treatment in decreasing the mortality[OR=0.21, 95%CI (0.17, 0.43)], improving oxygenation (24 h:[MD=49.59, 95%CI (24.36, 74.81)], 72 h:[MD=64.66, 95%CI (25.27, 104.04)] ), shortening the duration of mechanical ventila-tion [MD =-3.43, 95% CI (-4.23,-2.64)], reducing the incidence of ventilator-associated pneumoniathe (VAP) [MD=0.21, 95%CI (0.10, 0.42)] and curtailing the length of ICU stay [MD=-1.16, 95%CI (-1.65,-0.67)] was better than conventional treatment. Conclusion CVVH combined conventional treatment can de-crease the mortality, improve oxygenation, shorten the duration of mechanical ventilation, decrease the inci-dence of VAP and shorten the length of ICU stay in patients with ARDS. However, the clinical feasibility of the conclusions still needs further proofs.关键词
外科治疗连续性静脉-静脉血液滤过/连续性血液净化/连续性肾脏替代疗法/急性呼吸窘迫综合征/Meta分析/随机对照试验Key words
continuous veno-venous hemofiltration/continuous blood purification/continuous renal replace-ment therapy/acute respiratory distress syndrome/Meta-analysis/randomized controlled trial分类
医药卫生引用本文复制引用
王翠婷,董晨明,拜争刚..常规治疗联合连续性静脉-静脉血液滤过治疗急性呼吸窘迫综合征的Meta分析[J].兰州大学学报（医学版）,2015,(3):69-76,8.基金项目
国家自然科学基金项目 （）
