王晓鹏 1苏河 1田宏伟 1张苏钰 1吴自燕 1安亚莉 1马云涛1
作者信息
- 1. 甘肃省人民医院 干四普外科，兰州730000
- 折叠
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of magnesium isoglycyrrhizinate in the treatment of liver injury among pa-tients with obstructive jaundice after percutaneous transhepatic cholangiodrainage (PTCD).Methods Sixty-two obstructive jaundice pa-tients with liver injury after PTCD were randomly divided into treatment group (n=32)and control group (n=30).All patients were given vitamin B6 ,vitamin C,and coenzyme complex by intravenous drip.At the same time,the treatment group was given magnesium isoglycyr-rhizinate (100 mg)after PTCD for 7 days,while the control group was given reduced glutathione (1200 mg)for 7 days.After treatment, the improvements in serum alanine transaminase (ALT),aspartate aminotransferase (AST),albumin (Alb),γ-glutamyl transpeptidase (GGT),alkaline phosphatase (ALP),total bilirubin (TBil),direct bilirubin (DBil),tumor necrosis factor-α(TNFα),and nuclear factor-kappa B (NF-κB)were evaluated.The adverse reactions associated with magnesium isoglycyrrhizinate were observed.Results After treatment,both groups showed significant decreases in serum TBil,DBil,ALT,AST,ALP,TNFα,and NF-κB (P<0.05 ),and the treatment group had significantly higher decreases in these indices (P<0.05).However,there were no significant improvements in Alb and GGT in either group after treatment,and the two indices showed no significant differences between the two groups (P>0.05).Conclu-sion Treated with magnesium isoglycyrrhizinate,obstructive jaundice patients with liver injury after PTCD can regain the liver function and recover from jaundice rapidly,and magnesium isoglycyrrhizinate has good efficacy and safety.关键词
黄疸,阻塞性/经皮经肝胆管引流术/异甘草酸镁Key words
jaundice,obstructive/percutaneous transhepatic choledochus drainage/magnesium isoglycyrrhizinate分类
医药卫生
