临床肝胆病杂志Issue(8)：730-733,4.DOI:10.3969/j.issn.1001-5256.2014.08.007
自噬在急性胰腺炎发生发展中的作用
Role of autophagy in development and progression of acute pancreatitis
杨淑丽 1刘洁 2陈卫昌2
作者信息
- 1. 苏州卫生职业技术学院 内科教研室，江苏 苏州215009
- 2. 苏州大学附属第一医院 消化科，江苏 苏州215006
- 折叠
摘要
Abstract
Acute pancreatitis is considered an autodigestive disorder in which inappropriate activation of trypsinogen to trypsin within pancre-atic acinar cells leads to the development of pancreatitis.Autophagy is an evolutionarily preserved degradation process of cytoplasmic cellular constituents,and it is one of the early pathological processes in acute pancreatitis.Autophagic flux is impaired in acute pancreatitis,which mediates the key pathologic responses of this disease.Impaired autophagy,dysfunction of lysosomes,and dysregulation of autophagy suggest a disorder of the endolysosomal pathway in acute pancreatitis.The role of autophagy in acute pancreatitis is discussed from the aspects of au-tophagic process,autophagy and activation of trypsinogen,impaired autophagy and acute pancreatitis,and defective autophagy promoting in-flammation.关键词
胰腺炎/胰蛋白酶原/自噬/炎症/综述Key words
pancreatitis/trypsinogen/autophagy/inflammation/review分类
医药卫生引用本文复制引用
杨淑丽,刘洁,陈卫昌..自噬在急性胰腺炎发生发展中的作用[J].临床肝胆病杂志,2014,(8):730-733,4.
