临床肝胆病杂志Issue(8)：782-784,3.DOI:10.3969/j.issn.1001-5256.2014.08.021
特利加压素联合白蛋白治疗肝肾综合征24例分析
Therapeutic effect of terlipressin combined with albumin in 24 patients with hepatorenal syndrome
陈思 1孙长宇 1张致膗 1王莹莹1
作者信息
- 1. 郑州大学第一附属医院 感染科，郑州450052
- 折叠
摘要
Abstract
Objective To observe the therapeutic effect of terlipressin combined with albumin in management of patients with hepatorenal syndrome.Methods A retrospective study enrolling 46 patients with hepatorenal syndrome from May 201 1 to August 2013 was conducted, in which 22 patients were allocated to control group,and 24 patients to treatment group.In addition to conventional treatment,albumin was used in control group,and the patients in treatment group were treated with terlipressin plus albumin.Clinical symptoms,urine volume,ser-um creatinine,urea nitrogen,ascites,and prognosis were observed in the study.The Student′s t test was used for comparison between the two groups,and the chi-square test was used for comparison of rates.Results The treatment group showed significant improvements in clinical symptoms,while the control group did not.In treatment group,urine volume (ml/24 h)increased from (758.5 ±284.9)to (2277.1 ±704.8)(P<0.01);serum creatinine level (μmol/L)dropped from (234.2 ±87.2)to (126.8 ±62.2)(P<0.01);urea ni-trogen level (mmol/L)dropped from (18.1 ±6.4)to (10.3 ±4.5)(P<0.01);body weight (kg)dropped from (68.1 ±3.9)to (64.6 ±3.9)(P<0.01);abdominal circumference (cm)dropped from (95.0 ±5.1)to (90.8 ±4.9)(P<0.01).However,the control group showed no significant changes in urine volume,serum creatinine,urea nitrogen,body weight,and abdominal circumference after treatment (P>0.05).There were significant differences in these indices between the two groups after treatment (P<0.05).Significant differences in remission rate and survival rate were observed between the control group and treatment group (P<0.05 ).Conclusion A combination of terlipressin and albumin has favorable therapeutic effect on hepatorenal syndrome and improves the prognosis of patients with hepatorenal syndrome.关键词
肝肾综合征/血管收缩药/白蛋白类Key words
hepatorenal syndrome/vasoconstrictor agents/albumins分类
医药卫生引用本文复制引用
陈思,孙长宇,张致膗,王莹莹..特利加压素联合白蛋白治疗肝肾综合征24例分析[J].临床肝胆病杂志,2014,(8):782-784,3.
