临床肝胆病杂志Issue(9)：895-898,4.DOI:10.3969/j.issn.1001-5256.2014.09.014
ALT低于2倍正常值上限的慢性HBV感染者肝脏病理结果的预测因素分析
Analysis of predictors of liver injury stage in chronic HBV infection patients with ALT levels lower than 2 ×ULN
摘要
Abstract
Objective To investigate the role of various clinical parameters in predicting liver injury stage in patients with chronic hepatitis B virus (HBV)infection who had alanine aminotransferase (ALT)levels lower than 2 times the upper limit of normal (ULN).Methods Ultrasound-guided liver biopsy was performed in chronic HBV infection patients with ALT levels lower than 2 ×ULN.The activity of in-flammation and degree of fibrosis in liver tissues were assessed.Meanwhile,liver function,serum HBV markers,and HBV DNA were meas-ured.The role of these clinical parameters in predicting liver injury stage was evaluated by logistic regression analysis.Results Among 122 patients,94 (77.0%)had significant inflammation or fibrosis (G≥2 or S≥2),and 5 (4.1%)had early cirrhosis.There was significant difference in HBV DNA between G≥2 group and G <2 group,but other parameters showed no significant differences between the two groups.There were significant differences in age,HBeAg,HBV DNA,AST,and platelet count between S≥2 group and S<2 group.The logistic regression analysis showed that age,HBeAg,and AST were independent predictors of significant liver fibrosis (S≥2).Conclusion Liver biopsy is necessary for chronic HBV infection patients with serum ALT levels of <2 ×ULN,aged over 40 years,negative for HBeAg, or with serum AST levels of >40 U/L.关键词
肝炎病毒,乙型/丙氨酸转氨酶/活组织检查,针吸Key words
hepatitis B virus/alanine transaminase/biopsy,needle分类
医药卫生引用本文复制引用
杨瑞,张亚平,王昕红,朱斌,张光文..ALT低于2倍正常值上限的慢性HBV感染者肝脏病理结果的预测因素分析[J].临床肝胆病杂志,2014,(9):895-898,4.基金项目
河南省卫生科技创新型人才工程资助项目 （）
