临床肝胆病杂志Issue(9)：948-953,6.DOI:10.3969/j.issn.1001-5256.2014.09.028
非酒精性脂肪性肝病动物实验模型研究进展
Research advances in animal models of nonalcoholic fatty liver disease
摘要
Abstract
In recent years,the incidence of nonalcoholic fatty liver disease (NAFLD)has increased gradually along with the rising preva-lence of obesity,type 2 diabetes,and hyperlipidemia,and NAFLD has become one of the most common chronic liver diseases in the world and the second major liver disease after chronic viral hepatitis in China.However,its pathogenesis has not yet been clarified.Animal models are playing an important role in researches on NAFLD due to the facts that the development and progression of NAFLD require a long period of time,and ethical limitations exist in conducting drug trials in patients or collecting liver tissues from patients.The animal models with his-topathology similar to that of NAFLD patients are reviewed,and their modeling principle,as well as the advantages and disadvantages,are compared.Animal models provide a powerful tool for further studies of NAFLD pathogenesis and drug screening for prevention and treatment of NAFLD.关键词
脂肪肝/疾病模型,动物/小鼠/综述Key words
fatty liver/disease models,animal/mice/review分类
医药卫生引用本文复制引用
黄海燕,辛永宁,姜曼,金文文,姜相君,宣世英..非酒精性脂肪性肝病动物实验模型研究进展[J].临床肝胆病杂志,2014,(9):948-953,6.基金项目
国家自然科学基金 （）
