临床肝胆病杂志Issue(10)：1005-1008,4.DOI:10.3969/j.issn.1001-5256.2014.10.008
雌激素受体α-29位基因多态性与甘肃地区汉族HBV相关慢加急性肝衰竭患者的关系
Association of ERαgene polymorphism at position 29 with HBV -related acute -on -chronic liver failure
周宁 1张月荣 1魏世芳 1吴丽阳 1李象霖 1孙美英1
作者信息
- 1. 兰州市第一人民医院 感染科，兰州 730050
- 折叠
摘要
Abstract
Objective To investigate the relationship between estrogen receptor alpha (ERα)gene polymorphism at position 29 and hepatitis Bvirus (HBV)-related acute -on -chronic liver failure (HBV -ACLF)and the genetic pathogenesis of HBV -ACLF.Methods A total of 61HBV -ACLF patients,79 patients with chronic hepatitis B (CHB),and 69 patients who automatically recovered from HBV infection were includedin the study.The ERαgene polymorphism at position 29 was analyzed by polymerase chain reaction -restriction fragment length polymorphism.Theallele frequency was calculated by gene counting,and Hardy -Weinberg equilibrium test was performed.Confounding factors were adjusted by un-conditional logistic regression analysis.Comparisons of genotype frequency and allele frequency were made by chi -square test (R ×C).Results The frequencies of TT genotype and T allele of ERαgene at position 29 were significantly higher in HBV -ACLF patients than in CHB patients(55.7% vs 31.6%,χ2 =8.194,P =0.004;77.1% vs 54.4%,χ2 =15.341,P <0.001),and the risk of worsening in HBV infection patients withT allele was 2.811 times that in HBV infection patient with C allele (OR =2.811,95%CI:1.662 -4.753).The frequencies of TT genotype and Tallele of ERαgene at position 29 were significantly higher in HBV -ACLF patients than in patients who recovered from HBV infection (55.7% vs11.6%,χ2 =28.849,P <0.001;77.1% vs 32.6%,χ2 =51.401,P <0.001),and the risk of worsening in HBV infection patients with T allelewas 6.938 times that in patients with C allele (OR =6.938,95%CI:3.995 -12.050).Conclusion TT genotype and T allele of ERαgene at po-sition 29 might be the susceptibility gene for HBV -ACLF.关键词
肝功能衰竭/受体,雌激素/多态性,单核苷酸/多态性,限制性片段长度Key words
liver failure/receptor,estrogen/polymorphisms,single nucleotide/polymorphisms,restriction fragment length分类
医药卫生引用本文复制引用
周宁,张月荣,魏世芳,吴丽阳,李象霖,孙美英..雌激素受体α-29位基因多态性与甘肃地区汉族HBV相关慢加急性肝衰竭患者的关系[J].临床肝胆病杂志,2014,(10):1005-1008,4.
