临床肝胆病杂志Issue(10)：1087-1090,4.DOI:10.3969/j.issn.1001-5256.2014.10.028
白细胞介素28B基因多态性与慢性HBV、HCV感染的相关性
Research advances in associations between IL28B polymorphisms and chronic hepatitis B/C virus infection
摘要
Abstract
Chronic infection with hepatitis B /C virus (HBV /HCV)is a widespread epidemic in China.The single nucleotide polymorphisms (SNPs)in interleukin 28B (IL28B)gene have been associated with chronic HBV /HCV infection and response to interferon therapy.The biological functions and characteristics of IL28B are elaborated on,the associations between HCV infection and IL28B SNPs are commented on,and current reports of associations between HBV infection and IL28B SNPs are reviewed.The results support the associations between IL28B SNPs and disease progression of HCV infection or the curative effect of interferon therapy.However,contradictive results have been obtained in studies of associations between IL28B SNPs and disease progression of HBV infection,the incidence of liver cirrhosis and primary liver cancer after HBV infection,or the curative effect of interferon therapy,so further investigation is needed.关键词
肝炎,乙型/肝炎,丙型/白细胞介素类/多态性,单核苷酸/综述Key words
hepatitis B/hepatitis C/interleukins/polymorphism,single nucleotide/review分类
医药卫生引用本文复制引用
沈文娟,哈明昊..白细胞介素28B基因多态性与慢性HBV、HCV感染的相关性[J].临床肝胆病杂志,2014,(10):1087-1090,4.基金项目
浦东新区卫生系统学科带头人培养计划立项资助（PWRd2011-06）上海市浦东新区卫生局卫生科技发展专项基金资助（PW2012A -17）上海市卫生局科研课题立项资助 （）
