临床肝胆病杂志Issue(11)：1176-1178,3.DOI:10.3969/j.issn.1001-5256.2014.11.021
妊娠期病毒性肝炎临床特点分析
Analysis of clinical characteristics of viral hepatitis in pregnant women
摘要
Abstract
Objective To study the clinical characteristics of viral hepatitis in pregnancy.Methods A retrospective analysis was per-formed on 77 pregnant women with viral hepatitis who were admitted to our hospital from January 2009 to March 2013.Cause of hepatitis,se-rologic and virologic markers,degree of liver damage,and association with the stage of pregnancy were analyzed.Comparison of continuous data between groups was made by Kruskal-Wallis H test.Results The main cause of viral hepatitis in pregnancy was HBV infection (72 cases,93.51%),and 10.27%of patients were infected with hepatitis A,B or E virus.Moderate liver damage was detected in 64 patients (83.12%),severe liver damage in 7 patients (9.09%),and liver failure in 3 patients (3.90%).Sixteen patients (20.78%)were diag-nosed with hepatitis in the first trimester of pregnancy,49 (63.64%)in the second trimester,and 12 (15.58%)in the third trimester. Liver function indices,including total bile acid (TBA),total bilirubin (TBil),albumin (Alb),alanine aminotransferase (ALT),aspar-tate transaminase (AST),and prothrombin activity (PTA),were compared between HBeAg (+)and HBeAg (-)patients and between patients with HBV DNA >106 IU/ml and ≤106 IU/ml,and no significant differences were found in either comparison (P>0.05).Con-clusion Viral hepatitis in pregnancy is mainly caused by infection with hepatitis B virus.Liver damage is mostly moderate and severe liver damage and liver failure often occur in the middle or late stage of pregnancy.This study indicates that pregnant women should take precau-tions and active treatment for chronic hepatitis B.关键词
妊娠并发症,感染性/肝炎,病毒性,人/肝炎病毒,乙型Key words
pregnancy complications,infectious/hepatitis,viral,human/hepatitis B virus分类
医药卫生引用本文复制引用
刘惠媛,应若素,陈志敏,廖宝林,许敏..妊娠期病毒性肝炎临床特点分析[J].临床肝胆病杂志,2014,(11):1176-1178,3.基金项目
广州市科技计划项目 （）
