临床肝胆病杂志Issue(11)：1193-1197,5.DOI:10.3969/j.issn.1001-5256.2014.11.026
时间-强度曲线对肝脏占位性病变的诊断价值
Diagnostic value of time-intensity curve for hepatic space-occupying lesions
摘要
Abstract
Objective To analyze the diagnostic values of contrast-enhanced ultrasound (CEUS)and time-intensity curve (TIC)for al-pha-fetoprotein (AFP)-negative hepatocellular carcinoma (HCC),AFP-positive HCC,and hepatic hemangioma.Methods Patients with a confirmed diagnosis from October 2012 to October 2013 were divided into AFP-negative HCC group (24 patients),APP-positive HCC group (48 patients),and hepatic hemangioma group (76 patients).Routine ultrasound,CEUS,and TIC analysis were performed on the three groups.CEUS findings and TIC indices of the three groups were compared using χ2 test and independent-samples t test,respec-tively.Results There were significant differences in the CEUS findings during arterial and parenchymal phases between the AFP-negative HCC group and hemangioma group (χ2 =39.4,P=0.001;χ2 =78.9,P=0.001),as well as between the AFP-positive HCC group and hemangioma group (χ2 =50.6,P=0.001;χ2 =89.7,P=0.001),but no significant differences were observed in the CEUS findings dur-ing the same two phases between the AFP-negative HCC and AFP-positive HCC group (χ2 =0.036,P=0.85;χ2 =0.22,P=0.643). The time to peak (TP),peak intensity,area under the ROC curve (AUC),and mean transit time (MTT)for the AFP-negative HCC group were 27.52 ±4.11 s,49.52%±4.31%,1527.20 ±80.37%s,and 78.71 ±3.26 s,respectively,versus 28.28 ±4.09 s,50.20%±4.37%, 1725.08 ±78.46%s,and 79.21 ±3.32 s,respectively,for the AFP-positive HCC group,as well as 50.42 ±5.32 s,47.83%±4.29%, 1613.44 ±76.37%s,and 79.86 ±3.10 s,respectively,for the hemangioma group;there were significant ofifferences in TP among the three groups (F=568.63,P=0.001 ),there were no significant differences in peak intensity,AUC and MTT among the three groups (F=0.245,0.645,0.860,P>0.05).there were significant differences in TP between the AFP-negative HCC group and hemangioma group (P=0.001),as well as between the AFP-positive HCC group and hemangioma group (P=0.001),but no significant difference in TP was observed Objective To analyze the diagnostic values of contrast-enhanced ultrasound (CEUS)and time-intensity curve (TIC)for al-pha-fetoprotein (AFP)-negative hepatocellular carcinoma (HCC),AFP-positive HCC,and hepatic hemangioma.Methods Patients with a confirmed diagnosis from October 2012 to October 2013 were divided into AFP-negative HCC group (24 patients),APP-positive HCC group (48 patients),and hepatic hemangioma group (76 patients).Routine ultrasound,CEUS,and TIC analysis were performed on the three groups.CEUS findings and TIC indices of the three groups were compared using χ2 test and independent-samples t test,respec-tively.Results There were significant differences in the CEUS findings during arterial and parenchymal phases between the AFP-negative HCC group and hemangioma group (χ2 =39.4,P=0.001;χ2 =78.9,P=0.001),as well as between the AFP-positive HCC group and hemangioma group (χ2 =50.6,P=0.001;χ2 =89.7,P=0.001),but no significant differences were observed in the CEUS findings dur-ing the same two phases between the AFP-negative HCC and AFP-positive HCC group (χ2 =0.036,P=0.85;χ2 =0.22,P=0.643). The time to peak (TP),peak intensity,area under the ROC curve (AUC),and mean transit time (MTT)for the AFP-negative HCC group were 27.52 ±4.11 s,49.52%±4.31%,1527.20 ±80.37%s,and 78.71 ±3.26 s,respectively,versus 28.28 ±4.09 s,50.20%±4.37%, 1725.08 ±78.46%s,and 79.21 ±3.32 s,respectively,for the AFP-positive HCC group,as well as 50.42 ±5.32 s,47.83%±4.29%, 1613.44 ±76.37%s,and 79.86 ±3.10 s,respectively,for the hemangioma group;there were significant ofifferences in TP among the three groups (F=568.63,P=0.001 ),there were no significant differences in peak intensity,AUC and MTT among the three groups (F=0.245,0.645,0.860,P>0.05).there were significant differences in TP between the AFP-negative HCC group and hemangioma group (P=0.001),as well as between the AFP-positive HCC group and hemangioma group (P=0.001),but no significant difference in TP was observed between the AFP-negative HCC group and AFP-positive HCC group.Conclusion AFP-negative HCC (or AFP-positive HCC)and he-patic hemangioma can be diagnosed differentially by CEUS findings and TP.A combination of the two examinations can improve the diagnos-tic value for benign and malignant liver lesions and increase the detection rate of AFP-negative HCC.关键词
癌,肝细胞/血管瘤/超声造影/甲胎蛋白类Key words
carcinoma,hepatocellular/hemangioma/contrast-enhanced ultrasound/alpha-fetoproteins分类
医药卫生引用本文复制引用
王惠,南彩玲,马苏美,杨东红..时间-强度曲线对肝脏占位性病变的诊断价值[J].临床肝胆病杂志,2014,(11):1193-1197,5.基金项目
甘肃省消化系统肿瘤重点实验室开放课题 （）
