临床肝胆病杂志Issue(12)：1303-1306,4.DOI:10.3969/j.issn.1001-5256.2014.12.017
甘肃地区汉族和回族慢性乙型肝炎患者雌激素受体α-29位基因多态性分析
Analysis of ERα-29 polymorphisms between Han nationality and Hui minority populations with chronic hepatitis B in Gansu Province,China
周宁 1张月荣 1魏世芳 1吴丽阳 1李象霖1
作者信息
- 1. 兰州市第一人民医院 感染科，兰州730050
- 折叠
摘要
Abstract
Objective To investigate the genetic polymorphisms in the estrogen receptor (ER)alpha gene at position 29 (ERα-29)in pa-tients with chronic hepatitis B (CHB)from Han nationality and Hui minority populations in Gansu Province,China.Methods Polymorphisms of ERα-29 were analyzed in 84 Han and 84 Hui CHB patients who were admitted to our hospital from August 2012 to November 2013 by poly-merase chain reaction-restriction fragment length polymorphism analysis.Allele frequencies were determined by gene counting and tested for expectations of Hardy-Weinberg equilibrium.Unconditional logistic regression analysis was applied to adjust the confounding factors.Compar-ison of the genotype and allele frequencies was performed by chi-square test.Results The genotype frequencies of ERα-29 in Han versus Hui CHB patients from Gansu Province were as follows:TT,52.4%vs 60.7%;TC,40.5%vs 34.5%;CC,7.1%vs 4.8%.The allele fre-quencies were 72.6%vs 78.0%for the T allele and 27.4%vs 22.0%for the C allele.No significant differences in the allele and genotype frequencies of ERα-29 were found between Han and Hui CHB patients in Gansu Province (P>0.05 ).Conclusion The genetic polymor-phisms in ERα-29 are not significantly different between Han and Hui CHB patients in Gansu Province,China.关键词
肝炎,乙型,慢性/雌激素受体α/多态性,单核苷酸/甘肃/汉族/回族Key words
hepatitis B,chronic/estrogen receptor alpha/polymorphism,single nucleotide/GANSU/HAN NATIONALITY/HUI NA-TIONALITY分类
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周宁,张月荣,魏世芳,吴丽阳,李象霖..甘肃地区汉族和回族慢性乙型肝炎患者雌激素受体α-29位基因多态性分析[J].临床肝胆病杂志,2014,(12):1303-1306,4.
