临床肝胆病杂志Issue(1)：123-126,4.DOI:10.3969/j.issn.1001-5256.2015.01.028
HCV感染动物模型的研究进展
New progress in development of animal models of hepatitis C virus infection
摘要
Abstract
An animal model of hepatitis C virus (HCV)infection involves the use of an animal to build the model for simulating the whole process of HCV infection in humans.Establishing an ideal animal model for HCV infection is conducive to study on the pathogenesis of chro-nic hepatitis C,including virus-host interactions,viral variability,and host immune response patterns.Additionally,it provides a more ef-fective technical strategy for screening antiviral drugs and developing preventive vaccines.This article summarizes well-known animal mod-els of HCV infection,such as those established in chimpanzees,tree shrews,and mice.The advantages and drawbacks of each kind of ani-mal models are analyzed.In recent years,the establishment of small animal models,particularly those in transgenic mice,has opened up a new field in the development of animal models of HCV infection,which will be the hotspot and emphasis of relevant animal model studies.关键词
肝炎病毒属/模型,动物/感染/综述Key words
hepacivirus/model,animal/infection/review分类
医药卫生引用本文复制引用
朱婷,聂青和..HCV感染动物模型的研究进展[J].临床肝胆病杂志,2015,(1):123-126,4.基金项目
国家自然科学基金资助项目 （）
