临床肝胆病杂志Issue(1)：130-134,5.DOI:10.3969/j.issn.1001-5256.2015.01.030
肝细胞癌相关分子靶向治疗研究进展
Molecular targeted therapy for hepatocellular carcinoma
摘要
Abstract
Hepatocellular carcinoma (HCC)is the most common malignancy in the liver,for which surgical operation remains the primary treatment.However,the surgical treatment is associated with low resection rate and high recurrence rate,which drive studies on the mole-cule mechanism of initiation,metastasis,and invasion of HCC,in order to develop more effective early diagnosis and treatment methods.By reviewing related literature,this article summarizes the major signaling pathways related to HCC,such as the PI3K/AKT/mTOR signaling pathway,RAS/RAF/MEK/ERK signaling pathway,and VEGF/VEGFR,PDGFR,and FGFR signaling pathway.New advances in the cor-responding molecular targeted therapy for HCC are described,and the perspectives on future direction of relevant research are discussed.关键词
癌,肝细胞/靶向治疗/索拉非尼/综述Key words
carcinoma,hepatocellular/targeted therapy/solafenib/review分类
医药卫生引用本文复制引用
沈艺南(综述),卢军华(审校)..肝细胞癌相关分子靶向治疗研究进展[J].临床肝胆病杂志,2015,(1):130-134,5.基金项目
国家自然科学基金资助项目 （）
