临床肝胆病杂志Issue(4)：534-536,3.DOI:10.3969/j.issn.1001-5256.2015.04.014
乙型肝炎患者血清HBeAg和抗-HBe与HBV DNA定量的关系
Relationship between e system of hepatitis B and HBV DNA quantification
王菲 1许爱玲 1辛霞霞 1袁宏 2熊静静 1张琦 1王晨1
作者信息
- 1. 兰州大学第一临床医学院，兰州730000
- 2. 兰州大学第一医院 感染科，兰州730000
- 折叠
摘要
Abstract
Objective To analyze and compare the viral replication in patients with hepatitis B virus (HBV)when serum markers HBeAg and HBeAb are both positive,or HBeAg alone is positive,or HBeAb alone is positive,or both are negative.Methods Electrochemiluminescence method was used to detect serum markers of HBV,and the samples with HBeAg and HBeAb being both positive,or HBeAg alone being posi-tive,or HBeAb alone being positive,or both being negative were screened out,and the HBV DNA quantitative values of the samples were de-termined.Comparison of categorical data was made by chi-square test.Results Among 447 patients examined for serum markers of HBV,all were positive for HBsAg.HBeAg and HBeAb were simultaneously detected in 32 cases,with a positive rate of 7.16%.Of the 32 cases, 84.38%had HBV DNA levels of <5 ×102 copies/ml,12.50%had HBV DNA levels between 5 ×102 copies/ml and 1 ×104 copies/ml,and 3.13%had HBV DNA levels between 1 ×104 copies/ml and 1 ×107 copies/ml.The HBV DNA level of the HBeAg/HBeAb-positive group was significantly lower than that of the HBeAg-positive group (χ2 =13.21,P<0.01);the HBV DNA level of the HBeAb-positive group was significantly lower than that of the HBeAb-negative group (χ2 =74.12,P<0.01 ).A total of 218 cases had negative HBeAg,and 9 (4.13%)of them had HBV DNA levels of >1 ×104 copies/ml.Conclusion Being positive for both HBeAg and HBeAb is considered to be rare in the past;however,it is commonly seen clinically,and a proportion of patients have a relatively high level of viral replication.The viral replication weakens when HBeAb appears.In cases of negative serum HBeAg,some patients still show a high level of viral replication.There-fore,the presence or absence of HBeAg cannot be regarded as the evidence in the assessment of antiviral efficacy and infectivity.关键词
肝炎病毒,乙型/肝炎e抗原,乙型/肝炎抗体,乙型/病毒载量Key words
hepatitis B virus/hepatitis B e antigens/hepatitis B antibodies/viral burden分类
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王菲,许爱玲,辛霞霞,袁宏,熊静静,张琦,王晨..乙型肝炎患者血清HBeAg和抗-HBe与HBV DNA定量的关系[J].临床肝胆病杂志,2015,(4):534-536,3.
