临床肝胆病杂志Issue(4)：603-606,4.DOI:10.3969/j.issn.1001-5256.2015.04.031
HBV感染相关性肝病中调节性T淋巴细胞和辅助性T淋巴细胞17失衡的研究进展
Research progress in Treg/Th17 imbalance in persistent HBV infection
摘要
Abstract
Persistent infection with hepatitis B virus (HBV)is associated with host immune response.CD4 +T cells play an important role in HBV-specific immune response.The restoration of HBV-specific T-cell response after antiviral therapy using nucleoside and nucleo-tide analogues is also associated with CD4 +T cells.In recent years,two new subsets of CD4 +T cells,namely regulatory T cells (Tregs) and T helper 17 cells (Th17 cells),have been identified and shown to be related to disease progression and liver damage in patients with persistent HBV infection.Here we primarily summarized the differentiation and function of Tregs and Th17 cells and reviewed the interaction between the two types of cells in persistent infection and their changes after clinical antiviral therapy.We hope it will be helpful to clinical immunotherapy and prognostic assessment.关键词
肝炎病毒,乙型/T淋巴细胞,辅助诱导/T淋巴细胞,调节性/综述Key words
hepatitis B virus/T-lymphocytes,helper-inducer/T-lymphocytes,regulatory/review分类
医药卫生引用本文复制引用
程萍(综述),薛博瑜(审校)..HBV感染相关性肝病中调节性T淋巴细胞和辅助性T淋巴细胞17失衡的研究进展[J].临床肝胆病杂志,2015,(4):603-606,4.基金项目
国家中医药管理局国家中医临床研究基地业务建设科研专项 （）
