临床肝胆病杂志Issue(4)：614-617,4.DOI:10.3969/j.issn.1001-5256.2015.04.034
核苷和核苷酸类药物治疗慢性乙型肝炎过程中耐药突变株动态演变特征的研究进展
Research progress in dynamic evolution characteristics of nucleos(t)ide analogue-resistant mutants
摘要
Abstract
Long-term antiviral therapy with nucleos(t)ide analogues against hepatitis B virus may lead to the occurrence of drug-resistant viral mutations.As a challenging topic in antiviral research,the problem of drug-resistant mutations may be associated with the aggregation of chronic hepatitis B and the development of primary hepatic carcinoma.In-depth understanding of the evolution characteristics of drug-resistant mutants during long-term antiviral therapy will allow a selection of appropriate clinical drug resistance monitoring approach.Within the time interval between the occurrence of genotypic resistance and virological breakthrough,dynamic monitoring of variations in the propor-tion of drug-resistant variants in the quasispecies pool and timely change of the therapeutic regimen will help to optimize the treatment of chronic hepatitis B and develop effective antiviral drugs.关键词
乙型,肝炎,慢性/核苷类/核苷酸类/抗病毒药/抗药性/综述Key words
hepatitis B,chronic/nucleosides/nucleotides/antiviral agents/drug resistance/review分类
医药卫生引用本文复制引用
王扬,刘霜,周莉,郑素军,段钟平..核苷和核苷酸类药物治疗慢性乙型肝炎过程中耐药突变株动态演变特征的研究进展[J].临床肝胆病杂志,2015,(4):614-617,4.基金项目
“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项（2012ZX10002004－006、2013ZX10002002－006）；北京市卫生系统高层次卫生技术人才（2011－3－083）；北京市科委首都临床特色应用研究项目 （）
