临床肝胆病杂志Issue(4)：622-625,4.DOI:10.3969/j.issn.1001-5256.2015.04.036
白细胞介素28B基因多态性在慢性HBV感染及其治疗中的作用
Research progress in interleukin 28B polymorphisms in infection and treatment of chronic hepatitis B virus
张璨 1万卉 2陈红 3张凯3
作者信息
- 1. 兰州大学第一临床医学院，兰州730000
- 2. 兰州大学第一医院 感染科，兰州730000
- 3. 兰州大学第一医院 感染科，兰州730000
- 折叠
摘要
Abstract
The infection/clearance and antiviral therapy of hepatitis B virus (HBV)are affected by various factors,such as the host,virus, and environment.Recent studies have proven that interleukin 28B (IL-28B)polymorphisms are highly associated with the clearance and antiviral therapy of hepatitis C virus.Since then,great attention has been paid to the role of IL-28B genetic variations in chronic hepatitis B (CHB),with a research focus on the loci rs12979860,rs12980275,and rs8099917.This paper reviews the role of IL-28B polymor-phisms in the infection/clearance of HBV and interferon therapy of CHB.Despite the conflicting findings,IL-28B polymorphisms are con-sidered to have a potential clinical value in the field of CHB.关键词
肝炎,乙型,慢性/白细胞介素类/多态性,单核苷酸/综述Key words
hepatitis B,chronic/interleukins/polymorphism,single nucleotide/review分类
医药卫生引用本文复制引用
张璨,万卉,陈红,张凯..白细胞介素28B基因多态性在慢性HBV感染及其治疗中的作用[J].临床肝胆病杂志,2015,(4):622-625,4.
