临床肝胆病杂志Issue(5)：733-736,4.DOI:10.3969/j.issn.1001-5256.2015.05.024
热休克蛋白70的表达与 HBV 相关肝细胞癌临床病理学特征的相关性分析
Analysis of association between HSP70 expression in tumor tissues and clinicopathological characteristics of HBV -re-lated hepatocellular carcinoma
高加林 1杨宗国 1陈晓蓉 1徐庆年 1陆云飞1
作者信息
- 1. 复旦大学附属公共卫生临床中心，上海 201508
- 折叠
摘要
Abstract
Objective To investigate the relationship between heat shock protein 70 (HSP70)expression and clinicopathological character-istics of hepatitis virus B (HBV)-induced hepatocellular carcinoma (HCC).Methods Statistical analysis was conducted to explore the association between the data of HSP70 obtained from the gene expression omnibus (GEO)and the clinicopathological characteristics of HCC.As for categorical data,frequency (proportion)was used to describe and chi-square test or Fisher′s exact test was applied to ana-lyze.Univariate and multivariate logistic regression analyses were used to investigate the relationship between HSPexpression and the clini-copathological characteristics of HCC.The variables with a Pvalue less than 0.10 were included for subsequent multivariate analysis.Re-sults 1)The percentage of the HCC patients whose primary tumor sizes were more than 5 cm was significantly higher in the group with high expression of HSPA4L,HSPA6,and HSPA13 than in the group with low expression (P<0.05);in comparison with the group with high ex-pression of HSPA1A and HSPA6,the group with low expression had a significantly lower percentage of patients accompanied by liver cirrho-sis (P<0.05);there was a significantly higher percentage of patients with alpha-fetoprotein (AFP)levels more than 300 ng/ml in the group with high expression of HSPA5 and HSA13 compared with the group with low expression (P<0.01).2)The survival rates of HCC patients with liver cirrhosis and /or primary tumor that was more than 5 cm significantly decreased (P<0.05).3)Highly expressed HS-PA4L might promote the growth of HCC (OR =1.019,95% CI:1.006-10.032,P=0.003);the patients with high expression of HSPA1B might have a higher risk of developing multiple nodules (OR =1.002,95%CI:1.000-1.004,P=0.003).Conclusion The expression of HSPA4L and HSPA1B is,to some extent,associated with the clinicopathological characteristics of HCC,which might be a therapeutic tar-get and prognostic predictor for HCC.关键词
癌,肝细胞/HSP70热休克蛋白质类/肝炎病毒,乙型/病理学,临床Key words
carcinoma,hepatocellular/HSP70 heat -shock proteins/hepatitis B virus/pathology,clinical分类
医药卫生引用本文复制引用
高加林,杨宗国,陈晓蓉,徐庆年,陆云飞..热休克蛋白70的表达与 HBV 相关肝细胞癌临床病理学特征的相关性分析[J].临床肝胆病杂志,2015,(5):733-736,4.
