临床肝胆病杂志Issue(5)：766-770,5.DOI:10.3969/j.issn.1001-5256.2015.05.032
EBV 搞体与 EBV DNA 水平的影响因素及其相关性分析
A study of the relationship between EBV DNA and EBV antibody levels
摘要
Abstract
Objective To study the relationship between Epstein -Barr virus (EBV)DNA and EBV antibody levels.Methods A retrospec-tive study was conducted on 143 patients who underwent EBV DNA testing in serum and lymphocytes from January to August,2014.The clini-cal data,including age,sex,blood routine and biochemical examination,serum/lymphocyte EBV DNA,EBV -VCA -IgM,and EBV -VCA -IgG were recorded.Spearman correlation analysis was used to measure the degree of the relationships.Kruskal -Wallis H test or Mann -Whitney U test were applied to compare the differences between three or two groups.Results The spearman rank correlation coeffi-cient between serum EBV DNA and EBV -VCA -IgMlevels was 0.434 (P =0.00),while the correlation coefficients of serum EBV DNA level and EBV -VCA -IgMlevel with lymphocyte EBV DNA,alanine aminotransferase (ALT),aspartate aminotransferase (AST),alka-line phosphatase (ALP),gamma -glutamyl transpeptidase (GGT),white blood cells (WBC),and heterotypic lymphocytes ranged from 0.169 to 0.693 (P <0.05)and from 0.153 to 0.434 (P <0.05),respectively.The spearman rank correlation coefficient of lymphocyte EBV DNA with serum EBV DNA,EBV -VCA -IgM,AST,ALP,WBC,and heterotypic lymphocytes ranged from 0.207 to 0.693 (P <0.05).The positive rates of EBV DNA in lymphocytes and serum were 70.6% (101 /143)and 32.2% (46/143),respectively.The EBV -VCA-IgMpositive rate was 22.4% (32 /143),and 22.5% (25 /111)of the patients with negative EBV -VCA -IgMwere positive for serum EBV DNA.The overall positive rate for EBV -VCA -IgG was 91.6% (131 /143).The EBV -VCA -IgM positive rate in patients with positive serum EBV DNA (21 /46,45.7%)was significantly higher than that in patients with positive lymphocyte EBV DNA (29 /101, 28.7%)(χ2 =7.95,P <0.01).Conclusion Serum EBV DNA level is strongly correlated with EBV -VCA -IgMlevel.Moreover,ser-um EBV DNA exhibits a higher positive rate than EBV -VCA -IgM.Simultaneous detection of serum EBV DNA and EBV -VCA -IgM may benefit the diagnosis of current EBV infection.关键词
爱泼斯坦巴尔病毒感染/EBV DNAKey words
Epstein -Barr virus infections/EBV DNA分类
医药卫生引用本文复制引用
陆海英,魏秀琴,徐小元,于岩岩,吴赤红,刘丹..EBV 搞体与 EBV DNA 水平的影响因素及其相关性分析[J].临床肝胆病杂志,2015,(5):766-770,5.基金项目
国家十二五科技重大专项资助项目 （）
