临床骨科杂志Issue(4)：396-400,5.DOI:10.3969/j.issn.1008-0287.2014.04.014
不同时间给予氨甲环酸对减少全髋关节置换术中术后失血的影响
Different methods of tranexamic acid administration on reducing blood loss during total hip arthroplasty
张朋 1陈勇忠 1杨良锁 2王剑火 2邹仪强 1黄哲1
作者信息
- 1. 南京军区福州总院四七六医院骨科，福建 福州 350011
- 2. 舞阳县人民医院关节外科，河南 舞阳 462400
- 折叠
摘要
Abstract
Objective To compare the different timing of administration of tranexamic acid on total hip arthroplasty and postoperative blood loss. Methods 125 cases undergo total hip arthroplasty were randomly divided into five groups, 25 cases each. Patients in group A received 1g tranexamic acid intravenously 10min before the end of surger-y, group B received 1g tranexamic acid intravenously 10 min before the end of surgery and again in 7 hours after sur-gery, group C received 1g tranexamic acid intravenously 10 min before surgery, group D received 1g tranexamic acid 10 min before surgery and again 7 hours, group E was deemed as control group. Hemoglobin, hematocrit, bleeding time , activated partial thromboplastin time and other heamatological indices were compared in five groups and intraop-erative and postoperative blood loss were compared. Results Intraoperative blood loss, postoperative blood loss, de-creased hemoglobin values after the first day, perioperative hemoglobin decrease the maximum value, absolute amount of blood loss in five groups were statistically significant ( P<0. 05 ) . Group E five aspect values were significantly higher than the other groups (P<0. 05). Intraoperative blood loss, perioperative hemoglobin decrease the maximum value, absolute postoperative blood loss in group D were (272. 9 ± 46. 7) ml, (27. 8 ± 3. 8) g/L, (344. 4 ± 61. 6) ml, and were significantly less than in group A, B group and E group (P<0. 05). While the blood loss, postopera-tive hemoglobin decreased value of the first day in group C were ( 114. 7 ± 32. 7 ) ml, ( 21. 0 ± 3. 9 ) g/L, and were significantly lower than the group A, group B and group E (P<0. 05). Conclusions 1 g tranexamic acid 10 mi-nutes before surgery and 6 hours after the first administration was most effective for the reduction of blood loss during total hip arthroplasty.关键词
氨甲环酸/全髋关节置换/出血Key words
tranexamic acid/total hip arthroplasty/blood loss分类
医药卫生引用本文复制引用
张朋,陈勇忠,杨良锁,王剑火,邹仪强,黄哲..不同时间给予氨甲环酸对减少全髋关节置换术中术后失血的影响[J].临床骨科杂志,2014,(4):396-400,5.
