林产化学与工业Issue(3)：44-50,7.DOI:10.3969/j.issn.0253-2417.2014.03.008
碱性离子液体条件下烷基化壳聚糖衍生物的制备及其抑菌性能研究
Synthesis and Antibacterial Activity of Alkylated Chitosan Derivatives under Basic Ionic Liquid Condition
摘要
Abstract
Chitosan ( CTS) was alkalized by [ Bmim] OH basic ionic liquid in this study. Then the alkalized chitosan reacted with alkyl halides to prepare the alkylated chitosan with different substituents. The structures of alkylated products were characterized by IR and 1H NMR . The effects of reaction time, temperature and material ratio on the substitution degree ( DS ) of alkyl chitosan were also investigated and then the optimal reaction condition was obtained. The separated ionic liquid could be reused, and no noticeable changes of the DS for alkylated chitosan were observed when the reacted ionic liquid was reused for 3 times. The antibacterial properties of the target products were tested by the minimum inhibitory concentration method. Preliminary results indicated that those compounds had the antibacterial activity. In particular, ethyl chitosan(E-CTS), butyl chitosan(B-CTS), and dodecyl chitosan ( D-CTS ) exhibited excellent antibacterial activities against to Pseudomonas aeruginosa. The minimum inhibition concentration were 128,128 and 256 mg/L, respectively. Their antibacterial effects were better than commercially sold Ampicillin sodium while the C-CTS antibacterial effect was worse. The antibacterial activity of alkylated chitosan decreased with the increase of the DS and the length of carbon chain.关键词
碱性离子液体/碱化/烷基化/抑菌性能Key words
basic ionic liquid/alkalization/alkylation/antibacterial activity分类
化学化工引用本文复制引用
裴立军,蔡照胜,商士斌,宋湛谦..碱性离子液体条件下烷基化壳聚糖衍生物的制备及其抑菌性能研究[J].林产化学与工业,2014,(3):44-50,7.基金项目
国家自然科学基金资助项目(31170543) （31170543）
