林产化学与工业Issue(5)：67-72,6.DOI:10.3969/j.issn.0253-2417.2014.05.011
姜黄素衍生物的合成和生物活性研究
Synthesis and Biological Activity of Curcumin Derivatives
摘要
Abstract
Four curcumin derivatives were synthesized from curucmin and maleic anhydride by esterification, isomerization, chlorination and esterification. The yields of curcumin derivatives c1-c4 were 80. 5%, 83. 7%, 81. 2% and 85. 4%, respectively. Their structures were confirmed by IR, 1 H NMR and 13 C NMR. The antioxidative and antibacterial activities of target compounds c1 -c4 were evaluated. The IC50 values for scavenging of DPPH·were 164. 14 ± 0. 82, 166. 98 ± 0. 66, 171. 97 ± 0. 99 and 175. 10 ± 2. 34 mg/L, respectively. Their antioxidative activity was lower than that of curcumin (36. 22 ± 0. 22 mg/L). This proved the importance of phenolic OH. The target compounds c1 -c4 displayed high antibacterial activity, especially compound c4. The minimal inhibiting concentration(MIC) of c4 against Staphylococcus aureus, Escherichia coli, Penicillium sp. and Aspergillus niger were 0. 5, 0. 5, 0. 25 and 1. 0 g/L, respectively. There is hope to obtain antibacterial candidates by curcumin modification with α,β-unsaturated carbonyl compounds.关键词
姜黄素衍生物/合成/抗氧化活性/抗菌活性Key words
curcumin derivatives/synthesis/antioxidant activity/antibacterial activity分类
化学化工引用本文复制引用
旷春桃,李湘洲,薛海鹏,邓楠,王玲芝..姜黄素衍生物的合成和生物活性研究[J].林产化学与工业,2014,(5):67-72,6.基金项目
国家林业公益性行业科研专项(20120460103) （20120460103）
中南林业科技大学青年科学研究基金重点项目( QJ2010003A) （ QJ2010003A）
高等学校博士学科点专项基金项目(20094321110001) （20094321110001）
