临床口腔医学杂志Issue(7)：393-394,2.DOI:10.3969/j.issn.1003-1634.2014.07.004
自体牙本质片修复骨缺损的实验研究
Pilot study of autogenous tooth dentin graft to repair bone defect
摘要
Abstract
Objective:To investigate the feasibility of autogenous dentin block to repair the bone defect. Method:Autogenous grafts from freshly extracted teeth were rigidly fixed to the mandibular defects in eighteen rabbits using titanium screws in order to achieve good primary stability. Every six rabbits were stochastically sacrificed at 1,3 and 6 months after implantation respectively. For all specimens,radiographical and histological measurements were performed. Result:The boundaries of the grafts were distinctly visible in the implanted area during the first and third month. However,the teeth grafts were fully covered by new bone after sixth month. The radiograph demonstrated the progressive change in the bone and grafted tooth interface from radiolucency to radiopacity. Histologically,vascularization led to a temporary fibrous-integration in the graft-bone interface and grafts were gradually resorbed and replaced by new bone. Conclusion:Rigid fixation of auto-genous tooth dentin could serve as a novel approach for bone regeneration and to repair of bone defect.关键词
自体移植物/牙齿/坚固内固定/骨再生Key words
Autogenic graft/Tooth/Rigid fixation/Bone regeneration分类
医药卫生引用本文复制引用
秦旭,石玮,马博,许译文,陈卫民,周彬..自体牙本质片修复骨缺损的实验研究[J].临床口腔医学杂志,2014,(7):393-394,2.基金项目
国家自然科学基金（81171450）；湖北省自然科学基金（2011CDB539）；武汉市科技攻关项目 （）
