临床口腔医学杂志Issue(9)：515-518,519,5.DOI:10.3969/j.issn.1003-1634.2014.09.002
上皮间质转化相关基因在口腔鳞癌中的相关性及其与临床病理特征的关系研究
Relations of epithelial-mesenchymal transition-related gene and their correlations with clinicopathological fea-tures in oral squamous cell carcinoma
摘要
Abstract
Objective:To study the relationship of epithelial markers and transcription factors and confirm their func-tions in OSCC EMT and investigate their relationship between these factors and clinicopathologic features of OSCC in order to further reveal their roles during OSCC progression. Method:SP immunohistochemical method was used to detect the ex-pression of E-cad,Snail,Slug,MMP-2 and MMP-9 expression in 57 cases of OSCC and 10 cases of normal oral mucosa,an-alyze their relationship with clinicopathological factors of OSCC and correlation between E-cad and Snail,Slug,MMP-2, MMP-9 expression. Result: ①.In OSCC tissues,the positive rate of E-cad,Snail,Slug,MMP-2,MMP-9 respectively were 29.82%,75.43%,82.46%,71.93%,78.95%.2 (1) Expression of E-cad was related to differentiation degree of OSCC(P<0.05),but Snail,Slug,MMP-2,MMP-9 were not(P>0.05);②Expression of E-cad,Slug,MMP-2,MMP-9 had significantly positively correlated with invasion and lymph node metastasis(P<0.05),Snail has nothing to do with the invasion and lymph node metastasis(P>0.05). 3 The expression between E-cad and Snail,Slug,MMP-9 expression was negatively correlated in OSCC(P <0.05),but not related to MMP-2(P >0.05). Conclusion:Transcription factors and epithelial markers were corre-lated significantly,they were related to the invasion and lymph node metastasis and differentiation of oral squamous cell car-cinoma. These factors play a role in the different stages of EMT process, the interaction of them is an important part of the development of OSCC.关键词
口腔鳞癌/EMT/E-cad/Snail/Slug/MMP-2/MMP-9/浸润转移Key words
oral squamous cell carcinoma/EMT/E-cad/Snail/Slug/MMP-2/MMP-9/invasion and metastasis分类
医药卫生引用本文复制引用
赵志娟,袁宏伟,韦玄,孙红,云芬,贾永峰,施琳..上皮间质转化相关基因在口腔鳞癌中的相关性及其与临床病理特征的关系研究[J].临床口腔医学杂志,2014,(9):515-518,519,5.基金项目
教育部春晖计划合作项目（Z2012007）内蒙古自治区自然科学基金项目（2013MS1132）内蒙古自治区卫生和计划生育委员会医疗卫生科研计划项目 （）
