临床神经病学杂志Issue(2)：91-94,4.
急性脑梗死患者血浆 CXCL12水平的改变及其对预后的影响
Changes of plasma CXCL12 levels and their effects on the prognosis in acute cerebral infarction patients
摘要
Abstract
Objective To explore changes of plasma CXCL12 levels and their effects on the prognosis in acute cerebral infarction patients.Methods The plasma CXCL12 levels of 185 patients with acute cerebral infarctions ( cerebral infarction group) and 123 health people ( control group) were detected by ELISA.The patients with acute cerebral infraction were scored by the NIHSS and the mRS scales.The relativity between the plasma CXCL12 levels and the NIHSS scores were analyzed by Pearson correlation analysis.According to the mRS scores, the patients in the cerebral infarction group were divided into the good outcome subgroup ( mRS score 0 -2 ) and the poor outcome subgroup ( mRS score 3 -6 ) .The plasma CXCL12 levels between the two subgroups were compared, and then multiple Logistic regression analysis was taken.Results The plasma CXCL12 level in cerebral infraction group [(3.75 ±1.40)μg/ml] was significantly higher than that in control group [(0.96 ±0.67) μg/ml](P<0.01). Pearson correlation analysis showed that the plasma CXCL12 level in cerebral infraction group was negative correlated with the NIHSS score on admission (r=-0.857, P<0.01).The plasma CXCL12 level in good outcome subgroup [(4.56 ±1.24) μg/ml] was significantly higher than that in poor outcome subgroup [(2.75 ±0.84) μg/ml] (P<0.01).The Logistic regression analysis showed that the increase of plasma CXCL12 level was the independent protective factor for the poor prognosis ( OR =0.416, 95%CI:0.225 -0.768, P=0.005).Conclusions The plasma CXCL12 level is increased, which is the independent protective factor for the poor prognosis.It can be used as an important biological marker to evaluate the prognosis of acute cerebral infarction.关键词
脑梗死/CXCL12/预后/影响Key words
cerebral infraction/CXCL12/prognosis/effects分类
医药卫生引用本文复制引用
肖新兴,刘庆新,邹雪飞,鹿树军,陈金波..急性脑梗死患者血浆 CXCL12水平的改变及其对预后的影响[J].临床神经病学杂志,2015,(2):91-94,4.基金项目
山东省医药卫生科技发展计划项目 （）
