临床神经病学杂志Issue(2)：125-127,3.
艾滋病合并隐球菌性脑膜炎19例临床分析
Clinical analysis of 19 AIDS patients coinfected with cryptococcus meningitis
摘要
Abstract
Objective To observe the clinical features of AIDS coinfected with cryptococcus meningitis. Methods The clinical data of 19 AIDS patients coinfected with cryptococcus meningitis were retrospectively analyzed.Results Among 19 patients, the main clinical manifestation including headache (100.0%), nausea/vomiting (94.7%), fever (78.9%) and neck stiffness (84.2%).Seven cases revealed increased CSF protein, 10 cases showed depressed CSF glucose levels and 11 patients revealed elevated CSF pressures.The mean CD4+cell count was (58.9 ±27.8)/mm3.Imaging examination showed the neurological complications were hydrocephalus, cerebral infarction, cerebral atrophy and cerebral hernia.The usage rate of amphotericin B, amphotericin B liposome, fluconazole and fluorine cytosine was 31.6%, 21.1%, 47.4% and 47.4%, respectively.Only 2 cases received antiretroviral therapy.The misdiagnosis rate was 31.6%, and mortality rate was 21.1%.Conclusions AIDS coinfected with cryptococcus meningitis onsets hidden, with the clinical manifestation is atypical, and the misdiagnosis rate is higher.Early diagnosis and early usage of appropriate antifungal therapy/antiretroviral therapy can help to prevent the development of it.关键词
艾滋病/新型隐球菌性脑膜炎/临床特征Key words
AIDS/cryptococcus meningitis/clinical features分类
医药卫生引用本文复制引用
罗文静,黄文,莫雪安..艾滋病合并隐球菌性脑膜炎19例临床分析[J].临床神经病学杂志,2015,(2):125-127,3.基金项目
国家自然科学基金资助项目（81160152，81371333），广西自然科学基金资助项目 （）
