临床神经病学杂志Issue(3)：188-191,4.
帕金森病患者非运动症状波动的临床特点
Clinical features of fluctuations of non-motor symptoms in patients with Parkinson's disease
梁波 1黄磊 1李雪莲 1王尚培 1陈先文1
作者信息
- 1. 230022合肥，安徽医科大学第一附属医院神经内科
- 折叠
摘要
Abstract
Objective To explore clinical features of fluctuations of non-motor symptoms in patients with Parkinson's disease (PD).Methods Motor and non-motor fluctuations of 121 PD primary patients were assessed with Wearing-Off Questionnaire 19(WOQ-19);the symptoms of each item were further quantified by Visual analogue score ( VAS ) .The demographic and anti-parkinson medication data were collected , and the unified Parkinson 's disease rating scaleⅢ( UPDRSⅢ) and Hoehn-Yahr stage ( H-Y stage ) were used to evaluate motor functions and disease stages respectively.Results Of the 121 patients,114(94.2%)individuals showed non-motor symptoms and 44 (38.6%) patients presented non-motor fluctuation.Among the non-motor symptoms surveyed, anxiety, cloudy mind/dullness of thinking and mood changes had higher incidence rates ;some non-motor symptoms such as anxiety , mood changes , sweating and cloudy mind/dullness of thinking showed significantly higher incidence of fluctuations . Patients with neuropsychiatric symptoms (42.3%) had significantly higher fluctuation rate than patients with sensory symptoms (23.4%) and autonomic symptoms (27.9%)(all P<0.05).The VAS scores of anxiety,mood changes, cloudy mind/dullness of thinking, sweating, pain, aching, numbness and abdominal discomfort were significantly reduced after taking medcine(all P<0.05).Non-motor fluctuation patients had significantly longer disease duration and drug therapy duration,significantly higher H-Y stages,UPDRSⅢscores of on period and off period ,daily dose of compound levodapa and levodopa-equivalent daily dose than patients without non-motor fluctuation ( all P<0.05 ) . Patients with both motor and non-motor fluctuation had higher UPDRS Ⅲ scores ( off period ) and higher levodopa-equivalent daily dose than patients with only motor fluctuation (all P<0.05).Conclusions The prevalence of PD non-motor fluctuation is about 40%.Neuropsychiatric symptoms fluctuate more frequently .The occurrence of non-motor fluctuation are associated with including longer disease duration and therapy duration , higher H-Y stages and UPDRSⅢscores ,higher levodopa-equivalent daily dose and concomitant motor fluctuation .关键词
帕金森病/非运动症状/波动/临床特点Key words
Parkinson's disease/non-motor symptoms/fluctuation/clinical feature分类
医药卫生引用本文复制引用
梁波,黄磊,李雪莲,王尚培,陈先文..帕金森病患者非运动症状波动的临床特点[J].临床神经病学杂志,2015,(3):188-191,4.
