p38丝裂原活化蛋白激酶途径对大鼠脑缺血再灌注后脑组织基质金属蛋白酶－9表达及脑水肿形成的影响OA北大核心CSTPCD
Effect of p38 mitogen-activated protein kinase on expression of matrix metalloproteinase-9 and formation of cerebral edema in rats with cerebral ischemia-reperfusion
目的：探讨p38丝裂原活化蛋白激酶（ MAPK）途径对大鼠脑缺血再灌注后脑组织基质金属蛋白酶－9（MMP－9）表达及脑水肿形成的影响。方法54只 SPF 级雄性 SD 大鼠，随机分为假手术组（Sham组）、缺血再灌注组（ I／R组）和p38抑制剂组（ SB 组）。采用改良线栓法制备大鼠大脑中动脉缺血再灌注模型。再灌注24 h后对大鼠进行神经功能缺损评分，Evans Blue法测定血－脑屏障通透性；干湿比重法测定脑组织含水量，采用Western b…查看全部>>
Objective To investigate the effect of p 38 mitogen-activated protein kinase ( MARK) on expression of matrix metalloproteinase-9(MMP-9) and formation of cerebral edema in rats with cerebral ischemia-reperfusion. Methods Fifty-four SPF male SD rats were randomly divided into sham operation group ( Sham group ) , ischemia-reperfusion group(I/R group) and p38 inhibitor group(SB group).Middle cerebral artery ischemia-reperfusion model was made by modified line p…查看全部>>
李国辉;王耀辉
543002 桂林医学院附属梧州市红十字会医院神经内科桂林医学院附属医院神经内科
医药卫生
p38丝裂原活化蛋白激酶基质金属蛋白酶-9脑缺血再灌注脑水肿
p38 mitogen-activated protein kinasematrix metalloproteinase-9cerebral ischemia-reperfusioncerebral edema
《临床神经病学杂志》 2015 (3)
214-217,4
评论